ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2014
Neurophysiologic effect of GWAS derived schizophrenia and bipolar risk variants.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Genetic Determinants of Gating Functions: Do We Get Closer to Understanding Schizophrenia Etiopathogenesis?Frontiers in psychiatry · 2020Pooled it
- P300 in schizophrenia: Then and now.Biological psychology · 2024Review
- Novel missense variants in brain morphogenic genes associated with depression and schizophrenia.Frontiers in psychiatry · 2024Article
- Disturbed Oligodendroglial Maturation Causes Cognitive Dysfunction in Schizophrenia: A New Hypothesis.Schizophrenia bulletin · 2023Article
- Subfield-specific longitudinal changes of hippocampal volumes in patients with early-stage bipolar disorder.Bipolar disorders · 2023Article
- Smoking as a Common Modulator of Sensory Gating and Reward Learning in Individuals with Psychotic Disorders.Brain sciences · 2021Article
- Expression analysis and genotyping of DGKZ: a GWAS-derived risk gene for schizophrenia.Molecular biology reports · 2019Article
- Longitudinal trajectory of early functional recovery in patients with first episode psychosis.Schizophrenia research · 2019Article
- Associations between psychosis endophenotypes across brain functional, structural, and cognitive domains.Psychological medicine · 2018Article
- Altered apolipoprotein C expression in association with cognition impairments and hippocampus volume in schizophrenia and bipolar disorder.European archives of psychiatry and clinical neuroscience · 2017Article
- Endophenotype best practices.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2017Review
- Neuronal Deletion of Kmt2a/Mll1 Histone Methyltransferase in Ventral Striatum is Associated with Defective Spike-Timing-Dependent Striatal Synaptic Plasticity, Altered Response to Dopaminergic Drugs, and Increased Anxiety.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Multivariate Genetic Correlates of the Auditory Paired Stimuli-Based P2 Event-Related Potential in the Psychosis Dimension From the BSNIP Study.Schizophrenia bulletin · 2016Article
- Brain oscillations in bipolar disorder and lithium-induced changes.Neuropsychiatric disease and treatment · 2016Review
- Genomewide association analyses of electrophysiological endophenotypes for schizophrenia and psychotic bipolar disorders: a preliminary report.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2015Article
- Heterogeneity and individuality: microRNAs in mental disorders.Journal of neural transmission (Vienna, Austria : 1996) · 2015Review
- NR2B Antagonist CP-101,606 Abolishes Pitch-Mediated Deviance Detection in Awake Rats.Frontiers in psychiatry · 2014Article
- Multimodal assessments of the hippocampal formation in schizophrenia and bipolar disorder: evidences from neurobehavioral measures and functional and structural MRI.NeuroImage. Clinical · 2014Article
- Electrophysiological Endophenotypes for Schizophrenia.Harvard review of psychiatryReview
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Genome-wide association studies (GWAS) have identified multiple single nucleotide polymorphisms (SNPs) as disease associated variants for schizophrenia (SCZ), bipolar disorder (BPD), or both. Although these results are statistically robust, the functional effects of these variants and their role in the pathophysiology of SCZ or BPD remain unclear. Dissecting the effects of risk genes on distinct domains of brain function can provide important biological insights into the mechanisms by which these genes may confer illness risk. This study used quantitative event related potentials to characterize the neurophysiological effects of well-documented GWAS-derived SCZ/BPD susceptibility variants in order to map gene effects onto important domains of brain function. We genotyped 199 patients with DSM-IV diagnoses of SCZ or BPD and 74 healthy control subjects for 19 risk SNPs derived from previous GWAS findings and tested their association with five neurophysiologic traits (P3 amplitude, P3 latency, N1 amplitude, P2 amplitude, and P50 sensory gating responses) known to be abnormal in psychosis. The TCF4 SNP rs17512836 risk allele showed a significant association with reduced auditory P3 amplitude (P = 0.00016) after correction for multiple testing. The same allele was also associated with delayed P3 latency (P = 0.005). Our results suggest that a SCZ risk variant in TCF4 is associated with neurophysiologic traits thought to index attention and working memory abnormalities in psychotic disorders. These findings suggest a mechanism by which TCF4 may contribute to the neurobiological basis of psychotic illness.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.