ReviewBirth defects research. Part C, Embryo today : reviews2013
Prenatal effects of maternal consumption of polyphenol-rich foods in late pregnancy upon fetal ductus arteriosus.
Review in Birth defects research. Part C, Embryo today : reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 67 citations in OpenAlex.
- A randomized controlled trial investigating the impact of maternal dietary supplementation with pomegranate juice on brain injury in infants with IUGR.Scientific reports · 2021Trial
- Fetal Ductal Constriction, Pulmonary Hypertension and Atrial Septum Mobility: A Correlation Study.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026Article
- α-Adrenergic blockade impairs ductus venosus shunting during an acute period of fetal hypoxaemia without further deficits to cerebral oxygen delivery.Experimental physiology · 2026Article
- The First 1000 Days: Maternal Nutrient Intake-A Window of Opportunity for Pulmonary Hypertension-A Narrative Review.Nutrients · 2026Review
- Abnormal Fetal/Neonatal Lung Development Manifested as Some Functional Heart Abnormalities During the Third Trimester of Fetal Life.Biomedicines · 2025Article
- Prevalence of Cardiovascular Functional Anomalies in Large-for-Gestational-Age (LGA) Fetuses by Fetal Echocardiography.Journal of clinical medicine · 2025Article
- Article
- Premature Constriction of Fetal Ductus Arteriosus Caused by Sertraline in a Pregnant Woman: A Case Report.Clinical case reports · 2025Article
- Article
- Acute resveratrol exposure does not impact hemodynamics of the fetal sheep.Physiological reports · 2023Article
- Review
- Resveratrol and Reproductive Health.Life (Basel, Switzerland) · 2022Review
- Foetal ductus arteriosus constriction unrelated to non-steroidal anti-Inflammatory drugs: a case report and literature review.Annals of medicine · 2021Review
- A useful and simple tool to evaluate and compare the intake of total dietary polyphenols in different populations.Public health nutrition · 2021Article
- Air pollution and children's health-a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter.Environmental health and preventive medicine · 2021Review
- Maternal ingestion of cocoa causes constriction of fetal ductus arteriosus in rats.Scientific reports · 2021Article
- Naringin Supplementation during Pregnancy Induces Sex and Region-Specific Alterations in the Offspring's Brain Redox Status.International journal of environmental research and public health · 2021Article
- Alternative treatment for patent ductus arteriosus: a therapeutic challenge.Jornal vascular brasileiro · 2021Article
- Case Report: Persistent Pulmonary Hypertension of the Newborn and Narrowing of the Ductus Arteriosus After Topical Use of Non-Steroidal Anti-Inflammatory During Pregnancy.Frontiers in pharmacology · 2021Article
- Polyphenols in Farm Animals: Source of Reproductive Gain or Waste?Antioxidants (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fetal circulation has characteristic features, being morphologically and functionally different from extrauterine circulation. The ductus arteriosus plays a fundamental role in directing the blood flow to fetal inferior body parts. Basically, the ductus arteriosus directs 80-85% of the right ventricular output arising from the superior vena cava, coronary sinus, and a small part from the inferior vena cava to descending aorta. Its histological structure is made up predominantly by a thick muscular layer, differently from the aorta and the pulmonary artery, which increases with gestational age. The fibers have a circumferential orientation, especially at the external layers, facilitating and making effective ductal constriction. These factors may generate lumen alterations which may cause fetal and neonatal complications, such as heart failure, hydrops, neonatal pulmonary hypertension, and even death. Classically, maternal administration of indomethacin and/or other antiinflammatory drugs interfere in prostaglandins metabolism, causing ductal constriction. However, many cases of fetal ductal constriction, as well as of persistent neonatal pulmonary artery hypertension, remain without an established etiology, being referred as "idiopathic." In recent years, a growing body of evidence has shown that herbs, fruits, nuts, and a wide diversity of substances commonly used in daily diets have definitive effects upon the metabolic pathway of inflammation, with consequent inhibition of prostaglandins synthesis. This antiinflammatory action, especially of polyphenols, when ingested during the third trimester of pregnancy, may influence the dynamics of fetal ductus arteriosus flow. The goal of this review is to present these new observations and findings, which may influence dietary orientation during pregnancy.
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