ArticleJournal of medical virology2014
Search for varicella zoster virus DNA in saliva of healthy individuals aged 20-59 years.
Article in Journal of medical virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Salivary Varicella Zoster Virus DNA Detection in Patients With Acute Abdominal Pain: Frequency, Diagnostic Value, and Implications for Enteric Zoster.Journal of Korean medical science · 2025Article
- A fresh look at varicella vaccination.Human vaccines & immunotherapeutics · 2025Review
- Sequence analysis of isolated strains of herpes zoster virus among patients with shingles.Iranian journal of microbiology · 2024Article
- Silent Reactivation of Varicella Zoster Virus in Pregnancy: Implications for Maintenance of Immunity to Varicella.Viruses · 2022Article
- Association of Achalasia With Active Varicella Zoster Virus Infection of the Esophagus.Gastroenterology · 2021Article
- Varicella-Zoster Virus and the Enteric Nervous System.The Journal of infectious diseases · 2018Article
- Latent virus reactivation in astronauts on the international space station.NPJ microgravity · 2017Article
- Varicella Zoster Virus and Giant Cell Arteritis.The Journal of infectious diseases · 2016Article
- THE JEREMIAH METZGER LECTURE VARICELLA ZOSTER VIRUS: FROM OUTSIDE TO INSIDE.Transactions of the American Clinical and Climatological Association · 2016Article
- Use of Saliva to Identify Varicella Zoster Virus Infection of the Gut.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015Article
- Varicella zoster virus infection.Nature reviews. Disease primers · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
All neurological and ocular complications of varicella zoster virus (VZV) reactivation can occur without rash. Virological verification requires detection of VZV DNA or anti-VZV IgG antibody in cerebrospinal fluid (CSF), or anti-VZV IgM antibody in serum or CSF. If VZV were readily detected in other tissue in patients with neurological disease without rash and found to correlate with tests listed above, more invasive tests such as lumbar puncture might be obviated. Saliva is a potential source of VZV DNA. To study the potential diagnostic value of detecting VZV DNA in saliva from patients with neurological disease, saliva of healthy adults was searched for VZV DNA. A single saliva sample obtained by passive drool was centrifuged at 16,000g for 20 min. DNA was extracted from the supernatant and cell pellet and examined in triplicate for VZV DNA by real time PCR. A single random saliva sample from 80 healthy men and women aged 20-59 years revealed no VZV DNA (Table ), but was uniformly positive for cell (GAPdH) DNA. Because VZV DNA was not found in a random saliva sample from 80 individuals 20-59-year-old, a VZV-positive sample during neurologic disease may have potential significance. Further studies will determine whether VZV DNA in saliva correlates with VZV DNA or anti-VZV antibody in CSF in patients with neurological disease.
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