ArticleInternational journal of geriatric psychiatry2014
Omega-3 fatty acid biomarkers and subsequent depressive symptoms.
Article in International journal of geriatric psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Pooled it
- Effects of menopausal hormone therapy on erythrocyte n-3 and n-6 PUFA concentrations in the Women's Health Initiative randomized trial.The American journal of clinical nutrition · 2021Trial
- The association between plasma omega-3 fatty acids and suicidal ideation/self-harm in the United Kingdom Biobank.Lipids in health and disease · 2025Observational
- Article
- Sex differences in erythrocyte fatty acid composition of first-diagnosed, drug-naïve patients with major depressive disorders.Frontiers in pharmacology · 2023Article
- Red blood cell fatty acids and age-related macular degeneration in postmenopausal women.European journal of nutrition · 2022Article
- Association between dietary omega-3 fatty acid intake and depression in postmenopausal women.Nutrition research and practice · 2021Article
- Plasma polyunsaturated fatty acids and mental disorders in adolescence and early adulthood: cross-sectional and longitudinal associations in a general population cohort.Translational psychiatry · 2021Article
- Review
- Fatty acids and recurrence of major depressive disorder: combined analysis of two Dutch clinical cohorts.Acta psychiatrica Scandinavica · 2020Article
- Response to "International Society for Nutritional Psychiatry Research Practice Guidelines for Omega-3 Fatty Acids in the Treatment of Major Depressive Disorder" by Guu et al. (2019).Psychotherapy and psychosomatics · 2020Article
- Article
- Longitudinal Association betweenNutrients · 2018Article
- Focus on fatty acids in the neurometabolic pathophysiology of psychiatric disorders.Journal of inherited metabolic disease · 2018Review
- Omega-6 to omega-3 polyunsaturated fatty acid ratio and subsequent mood disorders in young people with at-risk mental states: a 7-year longitudinal study.Translational psychiatry · 2017Article
- Factors Associated With New-Onset Depression Following Ischemic Stroke: The Women's Health Initiative.Journal of the American Heart Association · 2017Observational
- Serum lipid changes following the onset of depressive symptoms in postmenopausal women.Psychiatry research · 2017Article
- Do sex hormones or hormone therapy modify the relation of n-3 fatty acids with incident depressive symptoms in postmenopausal women? The MESA Study.Psychoneuroendocrinology · 2017Article
- The Omega-3 Index Is Inversely Associated with Depressive Symptoms among Individuals with Elevated Oxidative Stress Biomarkers.The Journal of nutrition · 2016Article
- Longitudinal study of low serum LDL cholesterol and depressive symptom onset in postmenopause.The Journal of clinical psychiatry · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveWe sought to determine the relationship between the omega-3 fatty acid content of red blood cell membranes (RBC), in particular docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), and baseline and new-onset depressive symptoms in post-menopausal women. We secondarily sought to characterize the association between dietary omega-3 fatty acid intake and depressive symptomatology.
methodsStudy participants included 7086 members of the Women's Health Initiative Memory Study (aged 63-81 years) who had an assessment of RBC omega-3 fatty acid concentrations at the baseline screening visit. Depressive symptoms at baseline and follow-up were characterized using the Burnam eight-item scale for depressive disorders (Center for Epidemiologic Studies Depression Scale/Diagnostic Interview Schedule short form) and secondarily additionally inferred by antidepressant medication use.
resultsIn multivariable-adjusted models, our primary exposure, RBC DHA + EPA, was not related to depressive symptoms by any measure at baseline or follow-up, nor were RBC total omega-3, DHA, or EPA (all p > 0.2). In contrast, dietary intake of omega-3 was positively associated with depressive symptoms at baseline (adjusted odds ratio 1.082, 95% confidence interval 1.004-1.166; p = 0.04 for dietary DHA + EPA and Burnam score ≥0.06), although this generally did not persist at follow-up.
conclusionNo relationship between RBC omega-3 levels and subsequent depressive symptoms was evident, and associations between dietary omega-3 and depressive symptoms were variable. Biomarkers of omega-3 status do not appear to be related to risk of new depression in post-menopausal women.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.