Evidence map›Paper›PMID 24338487›Full record

ReviewCurrent allergy and asthma reports2014

Role of "Western diet" in inflammatory autoimmune diseases.

Arndt Manzel, Dominik N Muller, David A Hafler, Susan E Erdman, Ralf A Linker, Markus Kleinewietfeld

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Current allergy and asthma reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04894344 (Education to Decrease in Sodium Intake in University Students Evaluated With 24 Hour Urinary Sodium Excretion), which is not on this map. Cited by 233 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
233citing papers in PubMed, 9 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04894344 nacompletednot on this mapstarted 2020, after this paper: background citation

Education to Decrease in Sodium Intake in University Students Evaluated With 24 Hour Urinary Sodium Excretion: Randomized Controlled Trial

TypeinterventionalSponsorUniversidad Autonoma de Baja CaliforniaRan2020 to 2023Enrolled196ConditionsHypertension, Overweight or Obesity, Diabetes Mellitus, Type 2ArmsEducation group
3 · Its place in the literature

Who cites it

233 citing papers in PubMed, 9 syntheses or guidelines pooled it, 430 citations in OpenAlex.

  1. Pooled it
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  7. Dietary pattern in relation to the risk of Alzheimer's disease: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019
    Pooled it
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  10. Trial
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  15. Association between dietary inflammatory index and Bell's palsy: a retrospective case-control study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  16. The role of nutrition on thyroid health and disease: myths and facts.Journal of endocrinological investigation · 2026
    Review
  17. Article
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  19. Review
  20. Article

173 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Arndt ManzelDepartment of Neurology, University of Erlangen, Erlangen, Germany.
Dominik N Muller
David A Hafler
Susan E Erdman
Ralf A Linker
Markus Kleinewietfeld
Broad Institute · USFriedrich-Alexander-Universität Erlangen-Nürnberg · DEMassachusetts Institute of Technology · USMax Delbrück Center · DE

Funding

Role of Negative Costimulation in Regulation of AutoimmunityP01AI039671 · NIAID · YALE UNIVERSITY · PI David A. Hafler · 1996 to 2026
$51.7M
TOXICOLOGY CORE UNITP30ES002109 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LEVINE, STUART S · 1985 to 2020
$25.6M
TCR recognition of MHC class II peptide compexes in multiple sclerosisP01AI045757 · NIAID · DANA-FARBER CANCER INSTITUTE · PI WUCHERPFENNIG, KAI W · 1999 to 2017
$22.8M
Regulatory T Cells in Autoimmune DiseaseU19AI070352 · NIAID · YALE UNIVERSITY · PI HAFLER, DAVID A. · 2006 to 2011
$5.9M
Treatment of Autoimmune Disease by Costimulatory Signal*U19AI046130 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI KHOURY, SAMIA J. · 1999 to 2007
$5.6M
The role of the innate immune system on Treg reprogramming in human autoimmune diU01AI102011 · NIAID · YALE UNIVERSITY · PI HAFLER, DAVID A., HEROLD, KEVAN C · 2012 to 2016
$3.8M
GI Tract Dysbiosis and Breast CancerU01CA164337 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ERDMAN, SUSAN E, WANG, TIMOTHY CRAGIN · 2012 to 2016
$2.6M
ACE: Investigation of Innate Immunity in Multiple SclerosisR01AI091568 · NIAID · YALE UNIVERSITY · PI HAFLER, DAVID A. · 2010 to 2014
$1.6M
T CELLS IN THE CSF OF MULTIPLE SCLEROSIS PATIENTSR01NS024247 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI HAFLER, DAVID A. · 1987 to 2003
$1.2M
NCI NIH HHS U01 CA164337NIAID NIH HHS P01 AI039671NIAID NIH HHS P01 AI045757NIAID NIH HHS R01 AI091568NIAID NIH HHS U01 AI102011NIAID NIH HHS U19 AI046130NIAID NIH HHS U19 AI070352NIEHS NIH HHS P30 ES002109NIEHS NIH HHS P30-ES002109NINDS NIH HHS NS2427NINDS NIH HHS R01 NS024247
6 · The paper itself

Abstract

Developed societies, although having successfully reduced the burden of infectious disease, constitute an environment where metabolic, cardiovascular, and autoimmune diseases thrive. Living in westernized countries has not fundamentally changed the genetic basis on which these diseases emerge, but has strong impact on lifestyle and pathogen exposure. In particular, nutritional patterns collectively termed the "Western diet", including high-fat and cholesterol, high-protein, high-sugar, and excess salt intake, as well as frequent consumption of processed and 'fast foods', promote obesity, metabolic syndrome, and cardiovascular disease. These factors have also gained high interest as possible promoters of autoimmune diseases. Underlying metabolic and immunologic mechanisms are currently being intensively explored. This review discusses the current knowledge relative to the association of "Western diet" with autoimmunity, and highlights the role of T cells as central players linking dietary influences to autoimmune pathology.

Indexed as

DietFeeding BehaviorAnimalsAutoimmune DiseasesComorbidityHumansInflammationIntestinal MucosaLife StyleMicrobiotaObesityT-Lymphocytes, Helper-Inducer

Identifiers

PMID24338487
PMCPMC4034518
OpenAlexW1991229004

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.