ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2014
Orexigenic response to tail pinch: role of brain NPY(1) and corticotropin releasing factor receptors.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Brain regulation of gastric dysfunction induced by stress.Nature metabolism · 2023Article
- Binge eating, overeating and food addiction: Approaches for examining food overconsumption in laboratory rodents.Progress in neuro-psychopharmacology & biological psychiatry · 2023Review
- The Antagonism of Corticotropin-Releasing Factor Receptor-1 in Brain Suppress Stress-Induced Propofol Self-Administration in Rats.Frontiers in behavioral neuroscience · 2021Article
- Central somatostatin signaling and regulation of food intake.Annals of the New York Academy of Sciences · 2019Review
- Brain corticotropin-releasing factor signaling: Involvement in acute stress-induced visceral analgesia in male rats.Neurogastroenterology and motility · 2019Article
- The functional link between tail-pinch-induced food intake and emotionality and its possible role in stress coping in rats.The journal of physiological sciences : JPS · 2018Article
- Gut-Brain Neuroendocrine Signaling Under Conditions of Stress-Focus on Food Intake-Regulatory Mediators.Frontiers in endocrinology · 2018Review
- Posterodorsal Medial Amygdala Mediates Tail-Pinch Induced Food Intake in Female Rats.Journal of neuroendocrinology · 2016Article
- A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood.Journal of visualized experiments : JoVE · 2016Article
- Neuropeptide Y: A stressful review.Neuropeptides · 2016Review
- The role of brain somatostatin receptor 2 in the regulation of feeding and drinking behavior.Hormones and behavior · 2015Review
- Chronic and acute effects of stress on energy balance: are there appropriate animal models?American journal of physiology. Regulatory, integrative and comparative physiology · 2015Review
- Influence of Aging and Gender Differences on Feeding Behavior and Ghrelin-Related Factors during Social Isolation in Mice.PloS one · 2015Article
- Integrated circuits and molecular components for stress and feeding: implications for eating disorders.Genes, brain, and behavior · 2015Review
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Tail pinch stimulates food intake in rats. We investigated brain mechanisms of this response and the influence of repeated exposure. Sprague-Dawley rats received acute (5 min) or repeated (5 min/day for 14 days) tail pinch using a padded clip. Acute tail pinch increased 5-min food intake compared with control (0.92 ± 0.2 vs. 0.03 ± 0.01 g, P < 0.01). This response was inhibited by 76% by intracerebroventricular injection of BIBP-3226, a neuropeptide Y1 (NPY1) receptor antagonist, increased by 48% by astressin-B, a corticotropin-releasing factor (CRF) receptor antagonist, and not modified by S-406-028, a somatostatin subtype 2 antagonist. After the 5-min tail pinch without food, blood glucose rose by 21% (P < 0.01) while changes in plasma acyl ghrelin (+41%) and adrenocorticotropic hormone (+37%) were not significant. Two tail pinches (45 min apart) activate pontine and hindbrain catecholaminergic and hypothalamic paraventricular CRF neurons. After 14 days of repeated tail pinch, the 5-min orexigenic response was not significantly different from days 2 to 11 but reduced by 50% thereafter (P < 0.001). Simultaneously, the 5-min fecal pellet output increased during the last 5 days compared with the first 5 days (+58%, P < 0.05). At day 14, the body weight gain was reduced by 22%, with a 99% inhibition of fat gain and a 25% reduction in lean mass (P < 0.05). The orexigenic response to acute 5-min tail pinch is likely to involve the activation of brain NPY1 signaling, whereas that of CRF tends to dampen the acute response and may contribute to increased defecation and decreased body weight gain induced by repeated tail pinch.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.