ArticleJournal of pharmacokinetics and pharmacodynamics2014
Exponential tails of drug disposition curves: reality or appearance?
Article in Journal of pharmacokinetics and pharmacodynamics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Recalling the Definition of Basic Pharmacokinetic Parameters to Avoid Potential Pitfalls.European journal of drug metabolism and pharmacokinetics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since plasma drug concentration-time curves, C(t), can be examined only over a limited time range, it is unclear whether they have an exponential or power-law tail. An answer to this question is important because of the necessary extrapolation beyond the observation period (to infinity). Based on renewal theory, the present analysis shows that due to the recirculation process drug disposition curves become exponentially tailed also when the underlying organ transit time distributions have a power tail with exponent of -2 or smaller. Possible exceptions are drugs like amiodarone with anomalous distribution kinetics (deep tissue trapping) which are characterized by a power-law tail and an apparent lack of equilibrium distribution, corresponding to a fractional-in-time derivative formulation of kinetics.
Indexed as
Identifiers
24338373What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.