ArticleThe Journal of infectious diseases2014
PlasmoView: a web-based resource to visualise global Plasmodium falciparum genomic variation.
Article in The Journal of infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Molecular characteristics, clonal transmission, and risk factors ofFrontiers in microbiology · 2024Article
- Genomic Epidemiology and Antimicrobial Resistance Profiles ofInfection and drug resistance · 2023Article
- Genomic evolution and virulence association ofEmerging microbes & infections · 2021Article
- An open dataset ofWellcome open research · 2021Article
- Comparative Whole Genome Sequence Analysis and Biological Features ofFrontiers in microbiology · 2021Article
- Diversify and Conquer: The Vaccine Escapism ofMicroorganisms · 2020Review
- Immunity against sexual stage Plasmodium falciparum and Plasmodium vivax parasites.Immunological reviews · 2020Review
- Article
- Comparative Genome Analysis and Global Phylogeny of the Toxin Variant Clostridium difficile PCR Ribotype 017 Reveals the Evolution of Two Independent Sublineages.Journal of clinical microbiology · 2017Article
- Genetic diversity of the merozoite surface protein-3 gene in Plasmodium falciparum populations in Thailand.Malaria journal · 2016Article
- Genomic variation in two gametocyte non-producing Plasmodium falciparum clonal lines.Malaria journal · 2016Article
- From within host dynamics to the epidemiology of infectious disease: Scientific overview and challenges.Mathematical biosciences · 2015Review
- Genomic Epidemiology of a Protracted Hospital Outbreak Caused by a Toxin A-Negative Clostridium difficile Sublineage PCR Ribotype 017 Strain in London, England.Journal of clinical microbiology · 2015Article
- Dimorphism in genes encoding sexual-stage proteins of Plasmodium ovale curtisi and Plasmodium ovale wallikeri.International journal for parasitology · 2015Article
- Imputation-based population genetics analysis of Plasmodium falciparum malaria parasites.PLoS genetics · 2015Article
- Observing in real time the evolution of artemisinin resistance in Plasmodium falciparum.BMC medicine · 2015Article
- Directional selection at the pfmdr1, pfcrt, pfubp1, and pfap2mu loci of Plasmodium falciparum in Kenyan children treated with ACT.The Journal of infectious diseases · 2014Article
- Whole-genome scans provide evidence of adaptive evolution in Malawian Plasmodium falciparum isolates.The Journal of infectious diseases · 2014Article
- A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains.Nature communications · 2014Article
- Genome-wide analysis of selection on the malaria parasite Plasmodium falciparum in West African populations of differing infection endemicity.Molecular biology and evolution · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Funding
Abstract
Malaria is a global public health challenge, with drug resistance a major barrier to disease control and elimination. To meet the urgent need for better treatments and vaccines, a deeper knowledge of Plasmodium biology and malaria epidemiology is required. An improved understanding of the genomic variation of malaria parasites, especially the most virulent Plasmodium falciparum (Pf) species, has the potential to yield new insights in these areas. High-throughput sequencing and genotyping is generating large amounts of genomic data across multiple parasite populations. The resulting ability to identify informative variants, particularly single-nucleotide polymorphisms (SNPs), will lead to the discovery of intra- and inter-population differences and thus enable the development of genetic barcodes for diagnostic assays and clinical studies. Knowledge of genetic variability underlying drug resistance and other differential phenotypes will also facilitate the identification of novel mutations and contribute to surveillance and stratified medicine applications. The PlasmoView interactive web-browsing tool enables the research community to visualise genomic variation and annotation (eg, biological function) in a geographic setting. The first release contains over 600,000 high-quality SNPs in 631 Pf isolates from laboratory strains and four malaria-endemic regions (West Africa, East Africa, Southeast Asia and Oceania).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.