Observational studyEuropean heart journal. Acute cardiovascular care2013
Hyperglycemia at admission and during hospital stay are independent risk factors for mortality in high risk cardiac patients admitted to an intensive cardiac care unit.
Observational study in European heart journal. Acute cardiovascular care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Association Between Stress Hyperglycemia Ratio and Death in Patients With Moderate to Severe Tricuspid Regurgitation.Journal of the American Heart Association · 2026Observational
- Incidence and outcomes of early hyperglycaemia in critically ill patients.The Southern African journal of critical care : the official journal of the Critical Care Society · 2025Article
- Stress hyperglycemia ratio and risk of incident myocardial infarction in the general population: a large-scale cohort study.Frontiers in nutrition · 2025Article
- Prognostic effect of stress hyperglycemia ratio on patients with severe aortic stenosis receiving transcatheter aortic valve replacement: a prospective cohort study.Cardiovascular diabetology · 2024Article
- Continuous Glucose Monitoring Within Hospital: A Scoping Review and Summary of Guidelines From the Joint British Diabetes Societies for Inpatient Care.Journal of diabetes science and technology · 2023Article
- Selective protein kinase C inhibition switches time-dependent glucose cardiotoxicity to cardioprotection.Frontiers in cardiovascular medicine · 2022Article
- Diabetes mellitus exacerbates post-myocardial infarction heart failure by reducing sarcolipin promoter methylation.ESC heart failure · 2020Article
- The association between admission glucose levels and outcomes in adults admitted to a tertiary care hospital.Journal of community hospital internal medicine perspectives · 2019Article
- The Effect of Glycemic Control on Endothelial and Cardiac Dysfunction Induced by Red Blood Cells in Type 2 Diabetes.Frontiers in pharmacology · 2019Article
- Impact of an inpatient multidisciplinary glucose control management program.Archives of endocrinology and metabolism · 2018Article
- Role of Tight Glycemic Control during Acute Coronary Syndrome on CV Outcome in Type 2 Diabetes.Journal of diabetes research · 2018Review
- Outcomes of Less Intensive Glycemic Target for a Subcutaneous Insulin Protocol in Hospitalized Patients.The American journal of the medical sciences · 2015Article
- Relationship between admission blood glucose level and prognosis in elderly patients without previously known diabetes who undergo emergency non-cardiac surgery.Internal and emergency medicine · 2015Article
- Influence of a strict glucose protocol on serum potassium and glucose concentrations and their association with mortality in intensive care patients.Critical care (London, England) · 2015Observational
- Hyperglycemia-induced diaphragm weakness is mediated by oxidative stress.Critical care (London, England) · 2014Article
- COVID-19 and Diabetes: Understanding the Interrelationship and Risks for a Severe Course.Frontiers in endocrinologyReview
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsHyperglycemia is associated with increased mortality in cardiac patients. However, the predictive value of admission- and average glucose levels in patients admitted to an intensive cardiac care unit (ICCU) has not been described.
methodsObservational study of patients admitted to the ICCU of a tertiary medical center in whom glucose levels were measured at and during admission. Over a 19-month period, 1713 patients were included. Mean age was 63±14 years, 1228 (72%) were male, 228 (17%) had known diabetes. Median (interquartile) glucose levels at admission were 7.9 (6.5-10.1) mmol/l; median glucose levels during ICCU admission (873 patients with three or more measurements) were 7.3 (6.7-8.3) mmol/l. Cox regression analysis was performed including the variables age, gender, admission diagnosis, length of stay, prior (cardio)vascular disease and diabetes.
resultsA 1 mmol/l increase in admission glucose level (above 9 mmol/l) was associated with a 10% (95% confidence interval (CI): 7 -13%) increased risk for all-cause mortality. A 1 mmol/l higher average glucose level (above 8 mmol/l) was an additional independent predictor of mortality (HR 1.11, 95% CI: 1.03 - 1.20). At 30 days, 16.8% (97/579) of the patients with an admission glucose level in the highest tertile (>9.8 mmol/L) had died vs 5.2% (59/1134) of those with a lower admission glucose level.
conclusionIn a high risk ICCU population, both high admission glucose levels as well as high average glucose levels during hospitalization were independently associated with increased mortality, even when accounting for other risk factors and parameters of disease severity.
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