ArticleAge (Dordrecht, Netherlands)2014
The anti-aging effects of Ludwigia octovalvis on Drosophila melanogaster and SAMP8 mice.
Article in Age (Dordrecht, Netherlands), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 46 citations in OpenAlex.
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- Improving the effectiveness of anti-aging modalities by using the constrained disorder principle-based management algorithms.Frontiers in aging · 2022Review
- Dietary citrate supplementation enhances longevity, metabolic health, and memory performance through promoting ketogenesis.Aging cell · 2021Article
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- Network Pharmacology-Based Strategy to Investigate the Pharmacological Mechanisms ofEvidence-based complementary and alternative medicine : eCAM · 2020Article
- Anise HyssopFrontiers in physiology · 2020Article
- Ludwigia octovalvis (Jacq.) raven extract supplementation enhances muscle glycogen content and endurance exercise performance in mice.The Journal of veterinary medical science · 2019Article
- Serotonin receptor HTR6-mediated mTORC1 signaling regulates dietary restriction-induced memory enhancement.PLoS biology · 2019Article
- AMPK signaling linked to the schizophrenia-associated 1q21.1 deletion is required for neuronal and sleep maintenance.PLoS genetics · 2018Article
- Identification of Digestive Enzyme Inhibitors fromEvidence-based complementary and alternative medicine : eCAM · 2018Article
- Polysaccharides with Antioxidative and Antiaging Activities from Enzymatic-Extractable Mycelium byEvidence-based complementary and alternative medicine : eCAM · 2018Article
- Lycium Barbarum: A Traditional Chinese Herb and A Promising Anti-Aging Agent.Aging and disease · 2017Review
- Current Perspective in the Discovery of Anti-aging Agents from Natural Products.Natural products and bioprospecting · 2017Review
- Tequila Regulates Insulin-Like Signaling and Extends Life Span in Drosophila melanogaster.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015Article
- Anti-aging Effect and Gene Expression Profiling of Aged Rats Treated with G. bimaculatus Extract.Toxicological research · 2015Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the anti-aging effects of Ludwigia octovalvis (Jacq.) P. H. Raven (Onagraceae), an extract of which is widely consumed as a healthful drink in a number of countries. Using the fruit fly, Drosophila melanogaster, as a model organism, we demonstrated that L. octovalvis extract (LOE) significantly extended fly lifespan on a high, but not a low, calorie diet, indicating that LOE may regulate lifespan through a dietary restriction (DR)-related pathway. LOE also attenuated age-related cognitive decline in both flies and in the senescence-accelerated-prone 8 (SAMP8) mouse, without causing any discernable negative trade-offs, including water intake, food intake, fecundity, or spontaneous motor activity. LOE contained high levels of polyphenols and flavonoids, which possess strong DPPH radical scavenging activity, and was shown to attenuate paraquat-induced oxidative damage and lethality in flies. Gas chromatography-mass spectrometry (GC-MS) analyses identified 17 known molecules, of which β-sitosterol and squalene were the two most abundant. We further demonstrated that β-sitosterol was capable of extending lifespan, likely through activating AMP-activated protein kinase (AMPK) in the fat body of adult flies. Taken together, our data suggest that LOE is a potent anti-aging intervention with potential for treating age-related disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.