ArticleCellular and molecular neurobiology2014
DRG axon elongation and growth cone collapse rate induced by Sema3A are differently dependent on NGF concentration.
Article in Cellular and molecular neurobiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Genes in Axonal Regeneration.Molecular neurobiology · 2024Review
- Sema3A secreted by sensory nerve induces bone formation under mechanical loads.International journal of oral science · 2024Article
- Functional tissue-engineered microtissue formed by self-aggregation of cells for peripheral nerve regeneration.Stem cell research & therapy · 2022Article
- Vinaxanthone inhibits Semaphorin3A induced axonal growth cone collapse in embryonic neurons but fails to block its growth promoting effects on adult neurons.Scientific reports · 2021Article
- Biomimetic Approaches for Separated Regeneration of Sensory and Motor Fibers in Amputee People: Necessary Conditions for Functional Integration of Sensory-Motor Prostheses With the Peripheral Nerves.Frontiers in bioengineering and biotechnology · 2020Article
- Stimulating effect of thyroid hormones in peripheral nerve regeneration: research history and future direction toward clinical therapy.Neural regeneration research · 2018Review
- Semaphorin3A induces nerve regeneration in the adult cornea-a switch from its repulsive role in development.PloS one · 2018Article
- Asymmetric Sensory-Motor Regeneration of Transected Peripheral Nerves Using Molecular Guidance Cues.Scientific reports · 2017Article
- Macrophage and nerve interaction in endometriosis.Journal of neuroinflammation · 2017Review
- CRMP1 Interacted with Spy1 During the Collapse of Growth Cones Induced by Sema3A and Acted on Regeneration After Sciatic Nerve Crush.Molecular neurobiology · 2016Article
- Coculture of dorsal root ganglion neurons and differentiated human corneal stromal stem cells on silk-based scaffolds.Journal of biomedical materials research. Part A · 2015Article
- Microfluidic gradients reveal enhanced neurite outgrowth but impaired guidance within 3D matrices with high integrin ligand densities.Small (Weinheim an der Bergstrasse, Germany) · 2015Article
- CRMPs colocalize and interact with cytoskeleton in hippocampal neurons.International journal of clinical and experimental medicine · 2015Article
- An Automated Strategy for Unbiased Morphometric Analyses and Classifications of Growth Cones In Vitro.PloS one · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regeneration of embryonic and adult dorsal root ganglion (DRG) sensory axons is highly impeded when they encounter neuronal growth cone-collapsing factor semaphorin3A (Sema3A). On the other hand, increasing evidence shows that DRG axon's regeneration can be stimulated by nerve growth factor (NGF). In this study, we aimed to evaluate whether increased NGF concentrations can counterweight Sema3A-induced inhibitory responses in 15-day-old mouse embryo (E15) DRG axons. The DRG explants were grown in Neurobasal-based medium with different NGF concentrations ranging from 0 to 100 ng/mL and then treated with Sema3A at constant 10 ng/mL concentration. To evaluate interplay between NGF and Sema3A number of DRG axons, axon outgrowth distance and collapse rate were measured. We found that the increased NGF concentrations abolish Sema3A-induced inhibitory effect on axon outgrowth, while they have no effect on Sema3A-induced collapse rate.
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