ArticleJournal of autism and developmental disorders2014
Maternal immune-mediated conditions, autism spectrum disorders, and developmental delay.
Article in Journal of autism and developmental disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 6 syntheses or guidelines pooled it, 93 citations in OpenAlex.
- Maternal rheumatoid arthritis and the risk of offspring autism spectrum disorder: two national birth cohorts and a meta-analysis.Molecular autism · 2025Pooled it
- The Association Between Maternal Asthma and Child Autism: A Systematic Review and Meta-Analysis.Autism research : official journal of the International Society for Autism Research · 2025Pooled it
- Association between maternal asthma and ASD/ADHD in offspring: A meta-analysis based on observational studies.NPJ primary care respiratory medicine · 2025Pooled it
- Maternal atopic conditions and autism spectrum disorder: a systematic review.European child & adolescent psychiatry · 2024Pooled it
- Maternal acute and chronic inflammation in pregnancy is associated with common neurodevelopmental disorders: a systematic review.Translational psychiatry · 2021Pooled it
- Maternal Dietary Factors and the Risk of Autism Spectrum Disorders: A Systematic Review of Existing Evidence.Autism research : official journal of the International Society for Autism Research · 2020Pooled it
- Parental asthma and risk of autism spectrum disorder in offspring: A population and family-based case-control study.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019Trial
- Prenatal Exposure to Fine Particulate Matter Components and Autism Risk in Childhood.JAMA network open · 2025Article
- The relationship between neurodevelopmental disorders (NDDs) and NLRP3 inflammasome.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Review
- Association of the retinol to all-trans retinoic acid pathway with autism spectrum disorder.World journal of pediatrics : WJP · 2024Article
- Maternal Thyroid Dysfunction During Pregnancy as an Etiologic Factor in Autism Spectrum Disorder: Challenges and Opportunities for Research.Thyroid : official journal of the American Thyroid Association · 2024Review
- Prenatal allergic inflammation in rats confers sex-specific alterations to oxytocin and vasopressin innervation in social brain regions.Hormones and behavior · 2024Article
- Cognitive inflexibility and immunome biomarkers in children with autism spectrum disorder.Neuroscience applied · 2024Article
- Korean Clinical Guideline for Autism Spectrum Disorder - Clinical Features, Course, Epidemiology, and Cause.Journal of the Korean Academy of Child and Adolescent Psychiatry · 2024Article
- Inflammatory Conditions During Pregnancy and Risk of Autism and Other Neurodevelopmental Disorders.Biological psychiatry global open science · 2024Article
- Knowledge and awareness of autism spectrum disorder among Libyans.Journal of public health in Africa · 2023Article
- Perspective of adults in Saudi Arabia toward complementary and alternative medicine use for autism spectrum disorder: a cross-sectional study.BMC complementary medicine and therapies · 2023Article
- Characterizing the neuroimmune environment of offspring in a novel model of maternal allergic asthma and particulate matter exposure.Journal of neuroinflammation · 2023Article
- Prenatal air pollution, maternal immune activation, and autism spectrum disorder.Environment international · 2023Article
- Examining Prenatal Dietary Factors in Association with Child Autism-Related Traits Using a Bayesian Mixture Approach: Results from 2 United States Cohorts.Current developments in nutrition · 2023Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The maternal immune system may play a role in offspring neurodevelopment. We examined whether maternal autoimmune disease, asthma, and allergy were associated with child autism spectrum disorder (ASD) and developmental delay without autism (DD) using 560 ASD cases, 391 typically developing controls, and 168 DD cases from the CHildhood Autism Risk from Genetics and the Environment (CHARGE) study. Results from conditional logistic regression demonstrated few significant associations overall. Maternal autoimmune disease was significantly associated with a modest increase in odds of developmental disorders (combined ASD + DD; OR = 1.46, 95% CI 1.01, 2.09) but not of ASD alone. Associations with certain allergens and onset periods were also suggested. These findings suggest maternal autoimmune disease may modestly influence childhood developmental disorders (ASD + DD).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.