ArticleJournal of immunology (Baltimore, Md. : 1950)2014
EGFR signaling blunts allergen-induced IL-6 production and Th17 responses in the skin and attenuates development and relapse of atopic dermatitis.
Article in Journal of immunology (Baltimore, Md. : 1950), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Effects ofFrontiers in genetics · 2022Pooled it
- Contribution of epidermal growth factor (EGF) in the treatment of cutaneous leishmaniasis caused by Leishmania major in BALB/c mice.PLoS neglected tropical diseases · 2025Article
- Article
- Expression of an epidermal growth factor-transdermal peptide fusion protein inFrontiers in plant science · 2025Article
- Development of an Emulgel for the Effective Treatment of Atopic Dermatitis: Biocompatibility and Clinical Investigation.Gels (Basel, Switzerland) · 2024Article
- The use of epidermal growth factor in dermatological practice.International wound journal · 2023Review
- Air Pollution and Atopic Dermatitis, from Molecular Mechanisms to Population-Level Evidence: A Review.International journal of environmental research and public health · 2023Review
- Keratinocyte EGF signalling dominates in atopic dermatitis lesions: A comparative RNAseq analysis.Experimental dermatology · 2022Article
- Immunomodulatory Effect of Epidermal Growth Factor Secreted by Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells on Atopic Dermatitis.International journal of stem cells · 2022Article
- Differences in Behavior between Normal and Atopic Keratinocytes in Culture: Pilot Studies.Veterinary sciences · 2022Article
- Combination of FLG mutations and SNPs of IL-17A and IL-19 influence on atopic dermatitis occurrence.Postepy dermatologii i alergologii · 2022Article
- Transfer RNA-derived fragment tRF-28-QSZ34KRQ590K in plasma exosomes may be a potential biomarker for atopic dermatitis in pediatric patients.Experimental and therapeutic medicine · 2021Article
- Drug Repurposing for Atopic Dermatitis by Integration of Gene Networking and Genomic Information.Frontiers in immunology · 2021Article
- Gefitinib-Induced Cutaneous Toxicities in Brown Norway Rats Are Associated with Macrophage Infiltration.Inflammation · 2020Article
- Article
- Anti-Aging Effects of GDF11 on Skin.International journal of molecular sciences · 2020Review
- New Evidence and Insights on Dalbavancin and Wound Healing in a Mouse Model of Skin Infection.Antimicrobial agents and chemotherapy · 2020Article
- Topical administration of EGF suppresses immune response and protects skin barrier in DNCB-induced atopic dermatitis in NC/Nga mice.Scientific reports · 2018Article
- Potential protective effects of rhEGF against ultraviolet A irradiation-induced damages on human fibroblasts.Clinical, cosmetic and investigational dermatology · 2018Article
- Epidermal Growth Factor Relieves Inflammatory Signals inBioMed research international · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Despite the important role for epidermal growth factor (EGF) in epithelial homeostasis and wound healing, it has not been investigated in atopic dermatitis (AD). We used AD animal models to explore the role of EGF in AD. In an acute AD model, skin transepidermal water loss was significantly attenuated in EGF-treated mice. Blockade of EGFR signaling genetically or pharmacologically confirms a protective role for EGFR signaling in AD. In a chronic/relapsing AD model, EGF treatment of mice with established AD resulted in an attenuation of AD exacerbation (skin epithelial thickness, cutaneous inflammation, and total and allergen specific IgE) following cutaneous allergen rechallenge. EGF treatment did not alter expression of skin barrier junction proteins or antimicrobial peptides in the AD model. However, EGF treatment attenuated allergen-induced expression of IL-17A, CXCL1, and CXCL2 and neutrophil accumulation in AD skin following cutaneous allergen exposure. IL-17A production was decreased in the in vitro restimulated skin-draining lymph node cells from the EGF-treated mice. Similarly, IL-17A was increased in waved-2 mice skin following allergen exposure. Whereas IL-6 and IL-1β expression was attenuated in the skin of EGF-treated mice, EGF treatment also suppressed allergen-induced IL-6 production by keratinocytes. Given the central role of IL-6 in priming Th17 differentiation in the skin, this effect of EGF on keratinocytes may contribute to the protective roles for EGFR in AD pathogenesis. In conclusion, our study provides evidence for a previously unrecognized protective role for EGF in AD and a new role for EGF in modulating IL-17 responses in the skin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.