SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2014
The end-of-life phase of high-grade glioma patients: a systematic review.
Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence of symptoms in glioma patients throughout the disease trajectory: a systematic review.Journal of neuro-oncology · 2018Pooled it
- Seizure prophylaxis in glioma surgery: a synopsis from the SPRING RCT.Health technology assessment (Winchester, England) · 2026Trial
- "It's a club nobody wanted to join, but we're there": Focus groups on end-of-life care experiences and long-term outcomes of bereaved neuro-oncology caregivers.Palliative care and social practice · 2026Article
- Estimating Health State Utilities for IDH-Mutant Diffuse Glioma.PharmacoEconomics - open · 2025Article
- "I Got My Trophy": The Story of Implementing a Neuro-Oncology Exercise Program from the Patient and Caregiver Lens-A Qualitative Study.Current oncology (Toronto, Ont.) · 2025Article
- The feasibility of a multi-site, clinic-supported, and tailored neuro-oncology exercise program.Neuro-oncology practice · 2025Article
- Prospective assessment of end-of-life symptoms and quality of life in patients with high-grade glioma.Neuro-oncology practice · 2024Article
- Current status of advance care planning, palliative care consultation, and end-of-life care in patients with glioblastoma in South Korea.The oncologist · 2024Article
- Clinician perspectives on integrating neuro-oncology and palliative care for patients with high-grade glioma.Neuro-oncology practice · 2024Article
- What do carers of people with high-grade glioma perceive could improve their preparedness to care, and what additional support do they require?Neuro-oncology practice · 2024Article
- Palliative care implementation in neuro-oncology-Where do we come from, where do we go?Neuro-oncology practice · 2022Article
- ACE-Neuro: A tailored exercise oncology program for neuro-oncology patients - Study protocol.Contemporary clinical trials communications · 2022Article
- Comparison of the quality of death between primary malignant brain tumor patients and other cancer patients: results from a nationwide bereavement survey in Japan.Journal of neuro-oncology · 2022Article
- Easing the Journey-an Updated Review of Palliative Care for the Patient with High-Grade Glioma.Current oncology reports · 2022Review
- Modelling glioma progression, mass effect and intracranial pressure in patient anatomy.Journal of the Royal Society, Interface · 2022Article
- Adolescent and young adult brain tumors: current topics and review.International journal of clinical oncology · 2022Review
- Neuro-oncology and supportive care: the role of the neurologist.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Review
- Causes of Death and End-of-Life Care in Patients With Intracranial High-Grade Gliomas: A Retrospective Observational Study.Neurology · 2022Observational
- Caregiver perceptions of end-of-life care in patients with high-grade glioma.Neuro-oncology practice · 2021Article
- Quality of online self-management resources for adults living with primary brain cancer, and their carers: a systematic environmental scan.BMC palliative care · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHigh-grade gliomas (HGG) are rare and incurable; yet, these neoplasms result in a disproportionate share of cancer morbidity and mortality. Treatment of HGG patients is directed not merely towards prolonging life but also towards quality of life, which becomes the major goal in the end of life (EOL). The latter has received increasing attention over the last decade.
methodsWe reviewed the literature related to the EOL phase of HGG patients from 1966 up to April 2012. Articles were retrieved from PubMed, Embase, Cinahl, PsycINFO and Cochrane database. We then selected papers for analysis using pre-determined inclusion criteria and subtracted information on the topics of interest.
resultsThe search yielded 695 articles, of which 17 were classified eligible for analysis according to pre-defined inclusion criteria. Reviewed topics were symptoms and signs, quality of life and quality of dying, caregiver burden, organization and location of palliative care, supportive treatment, and EOL decision making. Nearly all identified studies were observational, with only two non-randomized intervention studies. Symptom burden is high in the EOL phase and affects the quality of life of both patient and carer. Palliative care services are more intensively used compared to other cancer patients. Cognitive deficits increase as the disease progresses, hampering communication and decision making.
conclusionThe EOL phase of HGG is substantially different from other patient groups, and more clinical studies in HGG on supportive medication, advance care planning and decision making are required. The organization of care, development of guidelines and interventions to decrease caregiver burden in the EOL phase are critical as well.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.