ArticleHistochemistry and cell biology2014
B lymphocyte compartments in the human splenic red pulp: capillary sheaths and periarteriolar regions.
Article in Histochemistry and cell biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Identity, ontogeny, and age-related changes in splenic white pulp macrophages in mouse and human spleen.bioRxiv : the preprint server for biology · 2026Article
- Clinical relevance of the compartments and lymphocyte subsets in the human spleen.Cell and tissue research · 2025Article
- Splenic stromal niches in homeostasis and immunity.Nature reviews. Immunology · 2023Review
- Anatomical structures, cell types and biomarkers of the Human Reference Atlas.Nature cell biology · 2021Review
- In focus in HCB.Histochemistry and cell biology · 2021Article
- Exploring human splenic red pulp vasculature in virtual reality: details of sheathed capillaries and the open capillary network.Histochemistry and cell biology · 2021Article
- Splenomegaly in Children and Adolescents.Frontiers in pediatrics · 2021Review
- Plasma cells, plasmablasts, and AIDHistochemistry and cell biology · 2020Article
- Activation of CD8⁺ T Cell Responses after Melanoma Antigen Targeting to CD169⁺ Antigen Presenting Cells in Mice and Humans.Cancers · 2019Article
- Locating human splenic capillary sheaths in virtual reality.Scientific reports · 2018Article
- Red pulp macrophages in the human spleen are a distinct cell population with a unique expression of Fc-γ receptors.Blood advances · 2018Article
- Comparison of Protein and Peptide Targeting for the Development of a CD169-Based Vaccination Strategy Against Melanoma.Frontiers in immunology · 2018Article
- Capillary networks and follicular marginal zones in human spleens. Three-dimensional models based on immunostained serial sections.PloS one · 2018Article
- Human spleen microanatomy: why mice do not suffice.Immunology · 2015Review
- The Histochemistry and Cell Biology pandect: the year 2014 in review.Histochemistry and cell biology · 2015Review
- Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The microvasculature of human spleens is still incompletely understood. Two enigmatic types of red pulp microvessels, penicillar arterioles and sheathed capillaries, have already been described in the nineteenth century without gaining much attention afterwards. We performed a detailed analysis of sheathed capillaries to clarify the cellular composition of their sheaths by immunohistological double-staining experiments. Capillary sheaths comprise three different cell types, namely specialized cuboidal CD271(++) inner sheath cells surrounded by CD271(-) macrophages and accumulations of B lymphocytes. The CD271(++) inner sheath cells express the chemokine CXCL13 in a unique single dot pattern. Sheath-associated B lymphocytes consist of IgM(+), IgD(++), and of "switched" cells. T lymphocytes do not accumulate in pericapillary sheaths. The predominant sheath-associated macrophage population is CD163(-)CD68(+) and thus differs from the majority of red pulp macrophages. The sheath-associated macrophages strongly express CD169 only in perifollicular sheaths, but not in sheaths located deeper in the red pulp. IgM(+), IgD(++), and "switched" B cells are also closely associated with red pulp arterioles characterized by the expression of smooth muscle actin in muscle cells and in branched periarteriolar stromal cells. Capillary sheaths are observed in a post-arteriolar position and appear to be of limited length. We suggest to change the term "Vagina periarteriolaris makrophagocytica" of the international histological and embryological terminologies to "Vagina pericapillaris."
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