Trial reportGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2014
A randomized trial to determine the diagnostic accuracy of conventional vs. jumbo forceps biopsy of gastric epithelial neoplasias before endoscopic submucosal dissection; open-label study.
Trial report in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Guideline
- How Commonly Is the Diagnosis of Gastric Low Grade Dysplasia Upgraded following Endoscopic Resection? A Meta-Analysis.PloS one · 2015Pooled it
- Development and validation of a predictive model for the pathological upgrading of gastric low-grade intraepithelial neoplasia.World journal of gastroenterology · 2025Article
- Risk factors analysis for pathological upgrade after endoscopic submucosal dissection in patients with gastric intraepithelial neoplasia: a single-center retrospective study.Therapeutic advances in gastroenterology · 2025Article
- Success rate of current human-derived gastric cancer organoids establishment and influencing factors: A systematic review and meta-analysis.World journal of gastrointestinal oncology · 2024Article
- [Approach for the Management of Indefinite-for-neoplasia Lesions Detected on Gastric Mucosal Biopsy].The Korean journal of helicobacter and upper gastrointestinal research · 2023Review
- Endoscopic submucosal dissection for gastric indefinite for neoplasia: which lesions should be resected?Surgical endoscopy · 2019Article
- Risk of multiple early gastric cancers in a patient with precursor lesions and endoscopic surveillance for 7 years: A case report.Medicine · 2019Article
- Treatment for gastric 'indefinite for neoplasm/dysplasia' lesions based on predictive factors.World journal of gastroenterology · 2019Article
- Pathologic outcomes of endoscopic submucosal dissection for gastric epithelial neoplasia.Medicine · 2018Observational
- Endoscopic small-capacity forceps increase the pathological diagnosis of gastric indefinite neoplasia.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2018Article
- Predictors of upstage diagnosis after endoscopic resection of gastric low-grade dysplasia.Surgical endoscopy · 2018Article
- The Diagnostic Accuracy of Conventional Forceps Biopsy Compared to ESD.Open medicine (Warsaw, Poland) · 2017Article
- Article
- Article
- Diagnosis and management of gastric dysplasia.The Korean journal of internal medicine · 2016Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsLarger biopsy specimens or increasing the number of biopsies may improve the diagnostic accuracy of gastric epithelial neoplasia (GEN). The aims of this study was to compare the diagnostic accuracies between conventional and jumbo forceps biopsy of GEN before endoscopic submucosal dissection (ESD) and to confirm that increasing the number of biopsies is useful for the diagnosis of GEN.
resultsThe concordance rate between EFB and ESD specimens was not significantly different between the two groups [83.1 % (54/65) in JG vs. 79.1 % (53/67) in CG]. On multivariate analyses, two or four EFBs significantly increased the cumulating concordance rate [coefficients; twice: 5.1 (P = 0.01), four times: 5.9 (P = 0.02)]. But, the concordance rate was decreased in high grade dysplasia (coefficient -40.32, P = 0.006). PATIENTS AND
methodsOne hundred and sixty GENs from 148 patients were randomized into two groups and finally 67 GENs in 61 patients and 65 GENs in 63 patients were allocated to the conventional group (CG) or jumbo group (JG), respectively. Four endoscopic forceps biopsy (EFB) specimens were obtained from each lesion with conventional (6.8 mm) forceps or jumbo (8 mm) forceps. The histological concordance rate between 4 EFB specimens and ESD specimens was investigated in the two groups.
conclusionsBefore ESD, the diagnostic accuracy of GENs was significantly increased not by the use of jumbo forceps biopsy but by increasing the number of biopsies.
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