ArticlePediatric nephrology (Berlin, Germany)2014
Pre- and post-treatment urinary tract findings in children with nephrogenic diabetes insipidus.
Article in Pediatric nephrology (Berlin, Germany), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 11 citations in OpenAlex.
- The natural history of untreated X-linked nephrogenic diabetes insipidus with mutation in the vasopressin V2 receptor gene.CEN case reports · 2025Article
- Diagnosing a genetic disease in a donor-conceived child: case report and discussion of the ethical, legal, and practical issues.Pediatric nephrology (Berlin, Germany) · 2025Review
- Ifosfamide-induced nephrogenic diabetes insipidus and Fanconi syndrome in a patient with femur osteosarcoma.Caspian journal of internal medicine · 2024Article
- Upper urinary dilatation and treatment of 26 patients with diabetes insipidus: A single-center retrospective study.Frontiers in endocrinology · 2022Article
- Transient minimal hydronephrosis on contralateral kidney in infants with unilateral hydronephrosis: Is it an early sign of worsening of the affected kidney?Turkish journal of medical sciences · 2021Article
- Nephrogenic diabetes insipidus in children (Review).Experimental and therapeutic medicine · 2021Review
- Identification of a Novel Arginine Vasopressin Receptor 2 Mutation (p.V183M) in a Chinese Family with Nephrogenic Diabetes Insipidus.Molecular syndromology · 2020Article
- Life with one kidney.Pediatric nephrology (Berlin, Germany) · 2018Review
- Poiseuille's law in polyuria.Pediatric nephrology (Berlin, Germany) · 2014Article
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3 authors at 1 institution in 1 country.
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Abstract
backgroundNephrogenic diabetes insipidus (NDI) is characterized by the kidney's inability to concentrate urine, which causes intense polyuria that may lead to urinary tract dilation. We report the morphological findings of the urinary tract in ten boys with NDI specifically addressing the presence and changes of urinary tract dilation during treatment. DIAGNOSIS/TREATMENT: Patients were diagnosed at a median age of 1.6 years (range, 0.16-6.33 years) and treated with a low osmotic diet, hydrochlorothiazide-amiloride and indomethacin, which decreased the diuresis from a median of 10.5 ml/kg/h to 4.4 ml/kg/h (p < 0.001). Three patients showed normal renal ultrasound before treatment until last control, while the remaining seven showed urinary tract dilation. In this second group, dilation was reduced with treatment in four patients and disappeared in the remaining three. Children without dilation or in whom the dilation disappeared were diagnosed and treated earlier than those with persistent dilation (median 1.66 versus 4.45 years, respectively). After a median of 10.4 (range, 2.3-20.3) years of follow-up, no patients showed urological complications.
conclusionsMedical treatment of the disease improved the dilation in all cases, preventing its potential complications. Regardless of the good outcome of our patients, periodic urologic follow-up is recommended in NDI patients.
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