Evidence map›Paper›PMID 24337300›Full record

ArticleScience (New York, N.Y.)2013

The genome of the ctenophore Mnemiopsis leidyi and its implications for cell type evolution.

Joseph F Ryan, Kevin Pang, Christine E Schnitzler, Anh-Dao Nguyen, R Travis Moreland, David K Simmons, Bernard J Koch, Warren R Francis, Paul Havlak, NISC Comparative Sequencing Program and 8 more

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 322 papers.

0numbers the graph read from it
0cells of the map it votes in
322citing papers in PubMed
142.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

322 citing papers in PubMed, 688 citations in OpenAlex.

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  11. Toward a genomic understanding of the tree of life.Molecular biology and evolution · 2026
    Article
  12. Article
  13. Review
  14. Article
  15. β-Catenin localization in the ctenophore Mnemiopsis leidyi suggests an ancestral role in cell adhesion and nuclear function.Developmental dynamics : an official publication of the American Association of Anatomists · 2025
    Article
  16. Review
  17. Article
  18. Article
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  20. Article

262 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 2 countries.

Joseph F RyanGenome Technology Branch, Division of Intramural Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Kevin Pang
Christine E Schnitzler
Anh-Dao Nguyen
R Travis Moreland
David K Simmons
Bernard J Koch
Warren R Francis
Paul Havlak
NISC Comparative Sequencing Program
Stephen A Smith
Nicholas H Putnam
Steven H D Haddock
Casey W Dunn
Tyra G Wolfsberg
James C Mullikin
Mark Q Martindale
Andreas D Baxevanis
National Human Genome Research Institute · USBrown University · USMonterey Bay Aquarium Research Institute · USWhitney Museum of American Art · USRice University · USUniversity of Bergen · NO

Funding

Inter- and Intra-Species Comparative SequencingZIBHG000196 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI THOMAS, JAMES · 2009 to 2025
$177.6M
Comparative Genomics Unit ResearchZIAHG200330 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI MULLIKIN, JAMES C · 2009 to 2022
$17.9M
Phylogenomic Studies on the Evolution of Morphological ComplexityZIAHG000140 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI BAXEVANIS, ANDREAS · 2009 to 2025
$11.4M
Structural /Phylogenetic Studies of Homeodomain ProteinZ01HG000140 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI BAXEVANIS, ANDREAS D. · 1999 to 2008
$1.4M
GAP FILLING IN CHROMOSOME SPECIFIC COSMID CONTIG MAPSF05HG000140 · NHGRI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KALACHIKOV, SERGEI M · 1995 to 1995
–
Intramural NIH HHS Z01 HG000140Intramural NIH HHS ZIA HG000140NHGRI NIH HHS F05 HG000140
6 · The paper itself

Abstract

An understanding of ctenophore biology is critical for reconstructing events that occurred early in animal evolution. Toward this goal, we have sequenced, assembled, and annotated the genome of the ctenophore Mnemiopsis leidyi. Our phylogenomic analyses of both amino acid positions and gene content suggest that ctenophores rather than sponges are the sister lineage to all other animals. Mnemiopsis lacks many of the genes found in bilaterian mesodermal cell types, suggesting that these cell types evolved independently. The set of neural genes in Mnemiopsis is similar to that of sponges, indicating that sponges may have lost a nervous system. These results present a newly supported view of early animal evolution that accounts for major losses and/or gains of sophisticated cell types, including nerve and muscle cells.

Indexed as

Biological EvolutionGenomeAnimalsBase SequenceCell LineageCtenophoraMesodermMolecular Sequence DataMuscle DevelopmentNeurogenesisPhylogeny

Identifiers

PMID24337300
PMCPMC3920664
OpenAlexW2164026798

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.