ArticleScience (New York, N.Y.)2013
Fear learning enhances neural responses to threat-predictive sensory stimuli.
Article in Science (New York, N.Y.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers.
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Who cites it
96 citing papers in PubMed, 188 citations in OpenAlex.
- The Unmet Need of Olfactory Testing in Inflammatory Disorders of the Upper Airways-An EAACI Position Paper.Allergy · 2026Review
- Experience and behavior modulate piriform cortex odor representation in freely moving mice.iScience · 2026Article
- The contribution of the koniocellular visual pathway to aversive learning in human visual cortex.Journal of neurophysiology · 2026Article
- Non-uniform endogenous regeneration of olfactory sensory neuron axons across the mouse olfactory bulb.Scientific reports · 2026Article
- Generalization of fear learning is shaped by inhibitory sensory processing in mice.Nature communications · 2026Article
- New Neurons in the Postnatal Olfactory System: Functions in the Healthy and Regenerating Brain.Brain sciences · 2025Review
- Perceptual constancy for an odor is acquired through changes in primary sensory neurons.Science advances · 2024Article
- Imaging different cell populations in the mouse olfactory bulb using the genetically encoded voltage indicator ArcLight.Neurophotonics · 2024Review
- A positive feedback inhibition of isocitrate dehydrogenase 3β on paired-box gene 6 promotes Alzheimer-like pathology.Signal transduction and targeted therapy · 2024Article
- Legacies of salient environmental experiences-insights from chemosensation.Chemical senses · 2024Article
- Robust odor identification in novel olfactory environments in mice.Nature communications · 2023Article
- Olfactory neurogenesis and its role in fear memory modulation.Frontiers in behavioral neuroscience · 2023Review
- Olfactory modulation of the medial prefrontal cortex circuitry: Implications for social cognition.Seminars in cell & developmental biology · 2022Review
- Article
- High trait anxiety blocks olfactory plasticity induced by aversive learning.Biological psychology · 2022Article
- Spatial transcriptomic reconstruction of the mouse olfactory glomerular map suggests principles of odor processing.Nature neuroscience · 2022Article
- Early Safety Discrimination Under Uncertainty in Trait Anxiety: An Event-Related Potential Study.Frontiers in human neuroscience · 2022Article
- Basolateral amygdala to posterior piriform cortex connectivity ensures precision in learned odor threat.Scientific reports · 2021Article
- Imputation of sensory properties using deep learning.Journal of computer-aided molecular design · 2021Article
- Associative learning shapes visual discrimination in a web-based classical conditioning task.Scientific reports · 2021Article
36 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The central nervous system rapidly learns that particular stimuli predict imminent danger. This learning is thought to involve associations between neutral and harmful stimuli in cortical and limbic brain regions, though associative neuroplasticity in sensory structures is increasingly appreciated. We observed the synaptic output of olfactory sensory neurons (OSNs) in individual mice before and after they learned that a particular odor indicated an impending foot shock. OSNs are the first cells in the olfactory system, physically contacting the odor molecules in the nose and projecting their axons to the brain's olfactory bulb. OSN output evoked by the shock-predictive odor was selectively facilitated after fear conditioning. These results indicate that affective information about a stimulus can be encoded in its very earliest representation in the nervous system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.