ArticleScience (New York, N.Y.)2013
Cryptic variation in morphological evolution: HSP90 as a capacitor for loss of eyes in cavefish.
Article in Science (New York, N.Y.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 167 papers.
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Who cites it
167 citing papers in PubMed, 16 citations in OpenAlex.
- Spliceosome buffers cryptic genetic variation to enforce phenotypic robustness inScience advances · 2026Article
- Disruption of carotenoid metabolism in cavefish via loss of beta-carotene oxygenase 2a.Current biology : CB · 2026Article
- Description of the second scale-developed and eyed Sinocyclocheilus (Cypriniformes: Cyprinidae) species from South Guizhou, China, with evolutionary implications.Journal of fish biology · 2026Article
- Physiological architecture and evolutionary origins of cellular adaptability.bioRxiv : the preprint server for biology · 2026Article
- Novel mechanisms of chemosensory adaptation to the cave environment.bioRxiv : the preprint server for biology · 2026Article
- Gim3 buffers and potentiates de novo mutations that affect fluconazole susceptibility in yeast.EMBO reports · 2026Article
- Hsp90 buffers behavioral variability by regulating Pdf transcription in clock neurons of Drosophila melanogaster.PLoS genetics · 2026Article
- Estimates of molecular convergence reveal multiple genes with adaptive variation across teleost fish.Molecular biology and evolution · 2026Article
- Water Parameters and Hydrodynamics in Rivers and Caves HostingEcology and evolution · 2026Article
- HSP90 buffers deleterious genetic variations in BRCA1.Molecular cell · 2025Article
- HSP90 as an evolutionary capacitor drives adaptive eye size reduction via atonal.Nature communications · 2025Article
- The evolution of cavefish odor perception shifts fish response from avoidance to approach when exposed to alarm and death odors.bioRxiv : the preprint server for biology · 2025Article
- Parallel sensory compensation following independent subterranean colonization by groundwater salamanders (Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Elevated Blood Hemoglobin in Different Cavefish Populations Evolves Through Diverse Hemoglobin Gene Expression Patterns.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2025Article
- Molecular mechanisms underlying the evolution of a color polyphenism by genetic accommodation in the tobacco hornworm,Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Hsp90: Bringing it all together.Cell stress & chaperones · 2025Review
- Stabilizing selection in an identified multisensory neuron in blind cavefish.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The Hsp90 Molecular Chaperone as a Global Modifier of the Genotype-Phenotype-Fitness Map: An Evolutionary Perspective.Journal of molecular biology · 2024Review
- Hypoxia-sonic hedgehog axis as a driver of primitive hematopoiesis development and evolution in cavefish.Developmental biology · 2024Article
- Selection for robust metabolism in domesticated yeasts is driven by adaptation to Hsp90 stress.Science (New York, N.Y.) · 2024Article
107 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
In the process of morphological evolution, the extent to which cryptic, preexisting variation provides a substrate for natural selection has been controversial. We provide evidence that heat shock protein 90 (HSP90) phenotypically masks standing eye-size variation in surface populations of the cavefish Astyanax mexicanus. This variation is exposed by HSP90 inhibition and can be selected for, ultimately yielding a reduced-eye phenotype even in the presence of full HSP90 activity. Raising surface fish under conditions found in caves taxes the HSP90 system, unmasking the same phenotypic variation as does direct inhibition of HSP90. These results suggest that cryptic variation played a role in the evolution of eye loss in cavefish and provide the first evidence for HSP90 as a capacitor for morphological evolution in a natural setting.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.