ArticleBiology open2013
Plasticity of lung development in the amphibian, Xenopus laevis.
Article in Biology open, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Biophysical processes of morphogenesis in lizard lungs.Developmental dynamics : an official publication of the American Association of Anatomists · 2026Article
- Phosphorescence lifetime microscopy and contrast-enhanced ultrasound imaging revealed strong left-to-right intraventricular shunt in anesthetized Xenopus laevis.The journal of physiological sciences : JPS · 2026Article
- Immune regulation and cellular crosstalk drive non-fibrotic lung remodeling in pre-metamorphic frogs exposed to paraquat.BMC biology · 2026Article
- Biophysical mechanisms of morphogenesis in lizard lungs.bioRxiv : the preprint server for biology · 2025Article
- Exploring the Role of a Putative Secondary Metabolite Biosynthesis Pathway inMicroorganisms · 2024Article
- Sox9 is associated with two distinct patterning events during snake lung morphogenesis.Developmental biology · 2024Article
- Recent advances in biomimetic hemostatic materials.Materials today. Bio · 2023Review
- Air-breathing behavior underlies the cell death in limbs of Rana pirica tadpoles.Zoological letters · 2023Article
- The cellular basis of cartilage growth and shape change in larval and metamorphosing Xenopus frogs.PloS one · 2023Article
- Developmental basis of evolutionary lung loss in plethodontid salamanders.Science advances · 2022Article
- From Water to Land: The Structural Construction and Molecular Switches in Lungs during Metamorphosis ofBiology · 2022Article
- Developing TadpoleInternational journal of molecular sciences · 2021Article
- Comparative Morphology of the Lungs and Skin of two Anura, Pelophylax nigromaculatus and Bufo gargarizans.Scientific reports · 2020Article
- Evaluation of Effective and Practical Euthanasia Methods for Larval African Clawed Frogs (Journal of the American Association for Laboratory Animal Science : JAALAS · 2020Article
- Development of central respiratory control in anurans: The role of neurochemicals in the emergence of air-breathing and the hypoxic response.Respiratory physiology & neurobiology · 2019Review
- Article
- Comparative transcriptome analyses reveal the genetic basis underlying the immune function of three amphibians' skin.PloS one · 2017Article
- Article
- Xenopus as a Model for GI/Pancreas Disease.Current pathobiology reports · 2015Article
- A Molecular atlas of Xenopus respiratory system development.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Contrary to previous studies, we found that Xenopus laevis tadpoles raised in normoxic water without access to air can routinely complete metamorphosis with lungs that are either severely stunted and uninflated or absent altogether. This is the first demonstration that lung development in a tetrapod can be inhibited by environmental factors and that a tetrapod that relies significantly on lung respiration under unstressed conditions can be raised to forego this function without adverse effects. This study compared lung development in untreated, air-deprived (AD) and air-restored (AR) tadpoles and frogs using whole mounts, histology, BrdU labeling of cell division and antibody staining of smooth muscle actin. We also examined the relationship of swimming and breathing behaviors to lung recovery in AR animals. Inhibition and recovery of lung development occurred at the stage of lung inflation. Lung recovery in AR tadpoles occurred at a predictable and rapid rate and correlated with changes in swimming and breathing behavior. It thus presents a new experimental model for investigating the role of mechanical forces in lung development. Lung recovery in AR frogs was unpredictable and did not correlate with behavioral changes. Its low frequency of occurrence could be attributed to developmental, physical and behavioral changes, the effects of which increase with size and age. Plasticity of lung inflation at tadpole stages and loss of plasticity at postmetamorphic stages offer new insights into the role of developmental plasticity in amphibian lung loss and life history evolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.