ArticlePsychopharmacology2014
Drugs of abuse as memory modulators: a study of cocaine in rats.
Article in Psychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 13 citations in OpenAlex.
- Memory enhancing effects of nicotine, cocaine, and their conditioned stimuli; effects of beta-adrenergic and dopamine D2 receptor antagonists.Psychopharmacology · 2021Article
- Analysis of memory modulation by conditioned stimuli.Learning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- Cocaine, nicotine, and their conditioned contexts enhance consolidation of object memory in rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Article
- Fructose:glucose ratios--a study of sugar self-administration and associated neural and physiological responses in the rat.Nutrients · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleIt has been proposed that drugs of abuse reinforce behavior partly, or wholly, because they facilitate learning by enhancing memory consolidation. Cocaine can clearly serve as a reinforcer, but its effect on learning has not been fully characterized.
objectivesTo explore the effects of different regimens of pre- and post-training cocaine administration on win-stay and object learning.
methodsCocaine naïve and cocaine pre-exposed (30 mg/kg/day, × 5 days followed by 7 days drug-free) male Sprague-Dawley rats received cocaine (0, 1, 2.5, 7.5, or 20 mg/kg, i.p.) immediately following training on a win-stay task in a radial maze or following the sample phase of an object learning task. Win-stay performance was also assessed in tests of extinction and after a set shift.
resultsPost-training cocaine did not improve accuracy on the win-stay task and produced performance deficits at 20 mg/kg. These deficits were attenuated by prior cocaine exposure. There was indirect evidence of facilitated learning in extinction and set shift tests, but the effective dosage was different (2.5 and 7.5 mg/kg, respectively). Post-training cocaine produced dose-dependent improvements in object learning.
conclusionPost-training cocaine administration can facilitate learning, but this effect is highly dependent on the dose and the type of task employed.
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