ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
DNA methylation and methyl-binding proteins control differential gene expression in distinct cortical areas of macaque monkey.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 15 citations in OpenAlex.
- An Overview of the Epigenetic Modifications in the Brain under Normal and Pathological Conditions.International journal of molecular sciences · 2024Review
- DNA methylation and transcriptome analysis reveal epigenomic differences among three macaque species.Evolutionary applications · 2024Article
- Article
- Expression patterns of SLIT/ROBO mRNAs reveal a characteristic feature in the entorhinal-hippocampal area of macaque monkeys.BMC research notes · 2020Article
- Eradication of cervical cancer in vivo by an AAV vector that encodes shRNA targeting human papillomavirus type 16 E6/E7.International journal of oncology · 2018Article
- Application of viral vectors to the study of neural connectivities and neural circuits in the marmoset brain.Developmental neurobiology · 2017Review
- The frontier of RNA metamorphosis and ribosome signature in neocortical development.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2016Review
- Distinct roles for primate caudate dopamine D1 and D2 receptors in visual discrimination learning revealed using shRNA knockdown.Scientific reports · 2016Article
- Postmitotic regulation of sensory area patterning in the mammalian neocortex by Lhx2.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Shaping the learning curve: epigenetic dynamics in neural plasticity.Frontiers in integrative neuroscience · 2014Article
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Distinct anatomical regions of the neocortex subserve different sensory modalities and neuronal integration functions, but mechanisms for these regional specializations remain elusive. Involvement of epigenetic mechanisms for such specialization through the spatiotemporal regulation of gene expression is an intriguing possibility. Here we examined whether epigenetic mechanisms might play a role in the selective gene expression in the association areas (AAs) and the primary visual cortex (V1) in macaque neocortex. By analyzing the two types of area-selective gene promoters that we previously identified, we found a striking difference of DNA methylation between these promoters, i.e., hypermethylation in AA-selective gene promoters and hypomethylation in V1-selective ones. Methylation levels of promoters of each area-selective gene showed no areal difference, but a specific methyl-binding protein (MBD4) was enriched in the AAs, in correspondence with expression patterns of AA-selective genes. MBD4 expression was mainly observed in neurons. MBD4 specifically bound to and activated the AA-selective genes both in vitro and in vivo. Our results demonstrate that methylation in the promoters and specific methyl-binding proteins play an important role in the area-selective gene expression profiles in the primate neocortex.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.