ArticleChemical communications (Cambridge, England)2014
Solution-phase-peptide synthesis via the group-assisted purification (GAP) chemistry without using chromatography and recrystallization.
Article in Chemical communications (Cambridge, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Insight into Protein Engineering: FromCurrent pharmaceutical design · 2025Review
- Development of a nitrogen-bound hydrophobic auxiliary: application to solid/hydrophobic-tag relay synthesis of calpinactam.Chemical science · 2023Article
- Super silyl-based stable protecting groups for both the C- and N-terminals of peptides: applied as effective hydrophobic tags in liquid-phase peptide synthesis.Chemical science · 2023Article
- Asymmetric Reactions ofMolecules (Basel, Switzerland) · 2023Review
- The Use of Peptides in Veterinary Serodiagnosis of Infectious Diseases: A Review.Veterinary sciences · 2022Review
- A Practical Peptide Synthesis Workflow Using Amino-Li-Resin.Methods and protocols · 2022Article
- Mercapto-functionalized polyhedral oligomeric silsesquioxane as a soluble support for the synthesis of peptide thioesters.Tetrahedron letters · 2021Article
- Liquid Phase Peptide Synthesis via One-Pot Nanostar Sieving (PEPSTAR).Angewandte Chemie (International ed. in English) · 2021Article
- Recent advances in synthetic and medicinal chemistry of phosphotyrosine and phosphonate-based phosphotyrosine analogues.RSC medicinal chemistry · 2020Review
- GAP Peptide SynthesisEuropean journal of organic chemistry · 2016Article
- A highly efficient group-assisted purification method for the synthesis of poly-functionalized pyrimidin-5-yl-pyrroles via one-pot four-component domino reaction.Molecular diversity · 2015Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The solution phase synthesis of N-protected amino acids and peptides has been achieved through the Group-Assisted Purification (GAP) chemistry by avoiding disadvantages of other methods in regard to the difficult scale-up, expenses of solid and soluble polymers, etc. The GAP synthesis can reduce the use of solvents, silica gels, energy and manpower. In addition, the GAP auxiliary can be conveniently recovered for re-use and is environmentally friendly and benign, and substantially reduces waste production in academic labs and industry.
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