ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2014
Magnetization transfer and adiabatic T1ρ MRI reveal abnormalities in normal-appearing white matter of subjects with multiple sclerosis.
Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Altering MRI rotating frame relaxations by changing the truncation level of Hyperbolic Secant pulse.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2026Article
- RJournal of magnetic resonance (San Diego, Calif. : 1997) · 2026Article
- Complete solution for rotating frame relaxation functions during adiabatic pulses.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2025Article
- Wide-spread brain alterations early after the onset of Crohn's disease in children in remission-a pilot study.Frontiers in neuroscience · 2024Article
- Quantitative magnetization transfer imaging in relapsing-remitting multiple sclerosis: a systematic review and meta-analysis.Brain communications · 2022Review
- Three-dimensional whole-brain simultaneous T1, T2, and T1ρ quantification using MR Multitasking: Method and initial clinical experience in tissue characterization of multiple sclerosis.Magnetic resonance in medicine · 2021Article
- Alterations in Sensorimotor and Mesiotemporal Cortices and Diffuse White Matter Changes in Primary Progressive Multiple Sclerosis Detected by Adiabatic Relaxometry.Frontiers in neuroscience · 2021Article
- Three-Dimensional GRE TMagnetic resonance in medicine · 2020Article
- Subcortical T1-Rho MRI Abnormalities in Juvenile-Onset Huntington's Disease.Brain sciences · 2020Article
- Rotating frame MRI relaxations as markers of diffuse white matter abnormalities in multiple sclerosis.NeuroImage. Clinical · 2020Article
- Proton Exchange Magnetic Resonance Imaging: Current and Future Applications in Psychiatric Research.Frontiers in psychiatry · 2020Review
- Brain T1ρ mapping for grading and IDH1 gene mutation detection of gliomas: a preliminary study.Journal of neuro-oncology · 2019Article
- Alterations of the cerebellum and basal ganglia in bipolar disorder mood states detected by quantitative T1ρ mapping.Bipolar disorders · 2018Article
- Bi-exponential 3D-T1ρ mapping of whole brain at 3 T.Scientific reports · 2018Article
- Differentiation of brain tumor-related edema based on 3D T1rho imaging.European journal of radiology · 2017Article
- Multi-modal Brain MRI in Subjects with PD and iRBD.Frontiers in neuroscience · 2017Article
- New rapid, accurate TNeuroImage. Clinical · 2017Article
- Peripheral inflammation during abnormal mood states in bipolar I disorder.Journal of affective disorders · 2015Article
- A longitudinal magnetization transfer imaging evaluation of brain injury in a macaque model of neuroAIDS.AIDS research and human retroviruses · 2015Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundDiffuse abnormalities are known to occur within the brain tissue of multiple sclerosis (MS) patients that is "normal appearing" on T1-weighted and T2-weighted magnetic resonance images.
objectivesWith the goal of exploring the sensitivity of novel MRI parameters to detect such abnormalities, we implemented an inversion-prepared magnetization transfer (MT) protocol and adiabatic T1ρ and T2ρ rotating frame relaxation methods.
methodsNine relapsing-remitting MS patients and seven healthy controls were recruited. Relaxation parameters were measured in a single slice just above the lateral ventricles and approximately parallel to the AC-PC line.
resultsThe MT ratio of regions encompassing the normal-appearing white matter (NAWM) was different in MS patients as compared with controls (p = 0.043); however, the T1 measured during off-resonance irradiation (T1sat) was substantially more sensitive than the MT ratio for detecting differences between groups (p = 0.0006). Adiabatic T1ρ was significantly prolonged in the NAWM of MS patents as compared to controls (by 6%, p = 0.026), while no differences were found among groups for T2ρ. No differences among groups were observed in the cortical gray matter for any relaxation parameter.
conclusionsThe results suggest degenerative processes occurring in the NAWM of MS, likely not accompanied by significant abnormalities in iron content.
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