Evidence map›Paper›PMID 24336226›Full record

ArticleNature immunology2014

Molecular signatures of antibody responses derived from a systems biology study of five human vaccines.

Shuzhao Li, Nadine Rouphael, Sai Duraisingham, Sandra Romero-Steiner, Scott Presnell, Carl Davis, Daniel S Schmidt, Scott E Johnson, Andrea Milton, Gowrisankar Rajam and 10 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03458780 (Single Cell Transcriptomics for Characterizing the Human Immune Response to Yellow Fever Vaccination), which is not on this map. Cited by 532 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
532citing papers in PubMed, 2 pooled it
19.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03458780 completednot on this mapstarted 2016, after this paper: background citation

Single Cell Transcriptomics for Characterizing the Human Immune Response to Yellow Fever Vaccination

TypeobservationalSponsorRockefeller UniversityRan2016 to 2018Enrolled6ConditionsHealthyArmsYellow Fever Vaccine
3 · Its place in the literature

Who cites it

532 citing papers in PubMed, 2 syntheses or guidelines pooled it, 791 citations in OpenAlex.

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472 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 1 country.

Shuzhao Li1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. [3].
Nadine Rouphael1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] The Hope Clinic of the Emory Vaccine Center, Division of Infectious Diseases, Emory University, Decatur, Georgia, USA. [3].
Sai Duraisingham1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. [3].
Sandra Romero-SteinerMeningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center of Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Scott Presnell1] Benaroya Research Institute, Seattle, Washington, USA. [2] Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, Texas, USA.ORCID 0000000192036403
Carl Davis1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA.
Daniel S SchmidtMeningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center of Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Scott E JohnsonMeningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center of Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Andrea MiltonMeningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center of Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Gowrisankar RajamMeningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center of Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Sudhir Kasturi1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
George M CarloneMeningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center of Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Charlie Quinn1] Benaroya Research Institute, Seattle, Washington, USA. [2] Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, Texas, USA.
Damien Chaussabel1] Benaroya Research Institute, Seattle, Washington, USA. [2] Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, Texas, USA.
A Karolina PaluckaBaylor Institute for Immunology Research, Baylor Research Institute, Dallas, Texas, USA.
Mark J Mulligan1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] The Hope Clinic of the Emory Vaccine Center, Division of Infectious Diseases, Emory University, Decatur, Georgia, USA. [3] Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA.
Rafi Ahmed1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, USA.
David S Stephens1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA.
Helder I Nakaya1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. [3] Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA.
Bali Pulendran1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. [3] Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA.
Emory University · USCenters for Disease Control and Prevention · USBaylor Institute for Rehabilitation · USBaylor University · US

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
Support Component D/Vaccine Discovery, Concept to ClinicUM1AI100663 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI GODZIK, ADAM · 2012 to 2018
$131.5M
YNPRC NHP CLINICAL MEDICINE RESIDENCY PROGRAM - SUPPLEMENTP51RR000165 · NCRR · EMORY UNIVERSITY · PI ALTMAN, JOHN DAVID · 1985 to 2011
$114.0M
Yessinia autotransporters (Yaps): Structure, function, and host responseU54AI057157 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SEMPOWSKI, GREGORY D · 2003 to 2013
$91.4M
VACCINE INDUCED IMMUNITY IN THE YOUNG AND AGEDU19AI057266 · NIAID · EMORY UNIVERSITY · PI Rafi Ahmed · 2003 to 2026
$81.7M
Systems Biological Analysis of Innate and Adaptive Responses to VaccinationU19AI090023 · NIAID · EMORY UNIVERSITY · PI AHMED, RAFI, LI, SHUZHAO · 2010 to 2021
$45.0M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025008 · NCRR · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2007 to 2011
$29.0M
Role of Follicular T Helper Cells In Enhancing Humoral Immunity and ProtectionU19AI096187 · NIAID · EMORY UNIVERSITY · PI DERDEYN, CYNTHIA ANN · 2011 to 2015
$26.5M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
Understanding the Role of Mucosal Antigen Presenting Cells in Regulating Immune ResponseR37AI048638 · NIAID · STANFORD UNIVERSITY · PI PULENDRAN, BALI · 2009 to 2018
$4.0M
Polarizing T Cell Responses in vivo With Dendritic CellsR37DK057665 · NIDDK · STANFORD UNIVERSITY · PI PULENDRAN, BALI · 2010 to 2019
$3.9M
POLARIZING T CELL RESPONSES IN VIVO WITH DENDRITIC CELLSR01DK057665 · NIDDK · EMORY UNIVERSITY · PI PULENDRAN, BALI · 2000 to 2009
$3.0M
NCATS NIH HHS UL1 TR000454NCRR NIH HHS P51 RR000165NCRR NIH HHS UL1 RR025008NIAID NIH HHS AI100663-02NIAID NIH HHS R37 AI048638NIAID NIH HHS R37AI48638NIAID NIH HHS R38 AI140299NIAID NIH HHS U19 AI057266NIAID NIH HHS U19AI057266NIAID NIH HHS U19 AI090023NIAID NIH HHS U19AI090023NIAID NIH HHS U19 AI096187NIAID NIH HHS U54 AI057157NIAID NIH HHS U54AI057157NIAID NIH HHS UM1 AI100663NIDDK NIH HHS R01 DK057665NIDDK NIH HHS R37 DK057665NIDDK NIH HHS R37DK057665NIH HHS P51 OD011132
6 · The paper itself

Abstract

Many vaccines induce protective immunity via antibodies. Systems biology approaches have been used to determine signatures that can be used to predict vaccine-induced immunity in humans, but whether there is a 'universal signature' that can be used to predict antibody responses to any vaccine is unknown. Here we did systems analyses of immune responses to the polysaccharide and conjugate vaccines against meningococcus in healthy adults, in the broader context of published studies of vaccines against yellow fever virus and influenza virus. To achieve this, we did a large-scale network integration of publicly available human blood transcriptomes and systems-scale databases in specific biological contexts and deduced a set of transcription modules in blood. Those modules revealed distinct transcriptional signatures of antibody responses to different classes of vaccines, which provided key insights into primary viral, protein recall and anti-polysaccharide responses. Our results elucidate the early transcriptional programs that orchestrate vaccine immunity in humans and demonstrate the power of integrative network modeling.

Indexed as

AdolescentAdultAntibody FormationComputer SimulationFemaleHumansImmunity, ActiveImmunoglobulinsInfluenza VaccinesMaleMeningococcal InfectionsMeningococcal VaccinesMiddle AgedNeisseria meningitidisSystems BiologyTranscriptomeImmunoglobulinsInfluenza VaccinesMeningococcal VaccinesVaccines, ConjugateYellow Fever Vaccine

Identifiers

PMID24336226
PMCPMC3946932
OpenAlexW1969218538

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.