Evidence map›Paper›PMID 24336101›Full record

ReviewNature reviews. Immunology2014

Human memory T cells: generation, compartmentalization and homeostasis.

Donna L Farber, Naomi A Yudanin, Nicholas P Restifo

Abstract readReview
In one paragraph

Review in Nature reviews. Immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 518 papers.

0numbers the graph read from it
0cells of the map it votes in
518citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

518 citing papers in PubMed.

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  5. Adaptive Immunity in Marsupials.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2026
    Review
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458 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Donna L Farber1] Columbia Center for Translational Immunology and Department of Microbiology and Immunology, Columbia University Medical Center, 650 West 168th Street, BB1501, New York, New York 10032, USA. [2] Department of Surgery, Columbia University Medical Center, 650 West 168th Street, BB1501, New York 10032, USA.
Naomi A YudaninColumbia Center for Translational Immunology and Department of Microbiology and Immunology, Columbia University Medical Center, 650 West 168th Street, BB1501, New York, New York 10032, USA.
Nicholas P RestifoNational Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

Funding

Transcriptomics and Repertoire ProfilingP01AI106697 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Donna L. Farber · 2013 to 2026
$31.3M
Building on the success of the adoptive immunotherapy of cancerZIABC010763 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI ROSENBERG, STEVEN · 2009 to 2020
$25.0M
The Impact of Bacterial Co-Infectin on Respiratory Virus-Specific T cell ResponseU19AI083022 · NIAID · WISTAR INSTITUTE · PI WHERRY, E. JOHN · 2009 to 2013
$10.7M
Development of lung T cell responses in infant respiratory immunityU01AI100119 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FARBER, DONNA L. · 2017 to 2021
$3.9M
Development of lung T cell responses in infant respiratory immunityR01AI100119 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FARBER, DONNA L. · 2012 to 2016
$2.6M
NIAID NIH HHS AI083022NIAID NIH HHS AI100119NIAID NIH HHS AI106697NIAID NIH HHS P01 AI106697NIAID NIH HHS R01 AI100119NIAID NIH HHS U01 AI100119NIAID NIH HHS U19 AI083022
6 · The paper itself

Abstract

Memory T cells constitute the most abundant lymphocyte population in the body for the majority of a person's lifetime; however, our understanding of memory T cell generation, function and maintenance mainly derives from mouse studies, which cannot recapitulate the exposure to multiple pathogens that occurs over many decades in humans. In this Review, we discuss studies focused on human memory T cells that reveal key properties of these cells, including subset heterogeneity and diverse tissue residence in multiple mucosal and lymphoid tissue sites. We also review how the function and the adaptability of human memory T cells depend on spatial and temporal compartmentalization.

Indexed as

Immunologic MemoryAdaptive ImmunityAnimalsAntigensCross ReactionsHomeostasisHumansImmunity, MucosalLymphoid TissueMiceMicrobiotaModels, ImmunologicalT-Lymphocyte SubsetsVaccinesAntigensVaccines

Identifiers

PMID24336101
PMCPMC4032067

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.