ArticleCell death & disease2013
Dual role of the caspase enzymes in satellite cells from aged and young subjects.
Article in Cell death & disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 45 citations in OpenAlex.
- Treating age-related loss of muscle mass and function: Where should we be focusing?The Journal of physiology · 2026Review
- Non-apoptotic role of caspase enzymes in satellite cells from human skeletal muscle.Biogerontology · 2026Article
- Extracellular Vesicles From Young Human Myogenic Progenitor Cells Rejuvenate Aged Cells.Biochemistry research international · 2026Article
- The impact of cellular senescence on aging skeletal muscle.Frontiers in cell and developmental biology · 2025Review
- Rejuvenating aged stem cells: therapeutic strategies to extend health and lifespan.FEBS letters · 2024Review
- Phloroglucinol Inhibits Oxidative-Stress-Induced Cytotoxicity in C2C12 Murine Myoblasts through Nrf-2-Mediated Activation of HO-1.International journal of molecular sciences · 2023Article
- Effects of Focused Vibrations on Human Satellite Cells.International journal of molecular sciences · 2022Article
- Trans-cinnamaldehyde protects C2C12 myoblasts from DNA damage, mitochondrial dysfunction and apoptosis caused by oxidative stress through inhibiting ROS production.Genes & genomics · 2021Article
- Synthesis and Biological Evaluation of HalogenatedMolecules (Basel, Switzerland) · 2020Article
- Essential amino acid supplementation alters the p53 transcriptional response and cytokine gene expression following total knee arthroplasty.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Stem Cell Aging in Skeletal Muscle Regeneration and Disease.International journal of molecular sciences · 2020Review
- Age-related decrease in muscle satellite cells is accompanied with diminished expression of early growth response 3 in mice.Molecular biology reports · 2020Article
- Neuromuscular Electrical Stimulation Induces Skeletal Muscle Fiber Remodeling and Specific Gene Expression Profile in Healthy Elderly.Frontiers in physiology · 2019Article
- Incorporation of macrophages into engineered skeletal muscle enables enhanced muscle regeneration.Nature biomedical engineering · 2018Article
- The AMPK/p27Stem cell reports · 2018Article
- Low-load resistance exercise during inactivity is associated with greater fibre area and satellite cell expression in older skeletal muscle.Journal of cachexia, sarcopenia and muscle · 2018Article
- Dietary resveratrol confers apoptotic resistance to oxidative stress in myoblasts.The Journal of nutritional biochemistry · 2017Article
- Karyopherin Alpha 1 Regulates Satellite Cell Proliferation and Survival by Modulating Nuclear Import.Stem cells (Dayton, Ohio) · 2016Article
- Live imaging of muscle histolysis in Drosophila metamorphosis.BMC developmental biology · 2016Article
- The Regenerative Potential of Female Skeletal Muscle upon Hypobaric Hypoxic Exposure.Frontiers in physiology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Satellite cell (SC) proliferation and differentiation have critical roles in skeletal muscle recovery after injury and adaptation in response to hypertrophic stimuli. Normal ageing hinders SC proliferation and differentiation, and is associated with increased expression of a number of pro-apoptotic factors in skeletal muscle. In light of previous studies that have demonstrated age-related altered expression of genes involved in SC antioxidant and repair activity, this investigation was aimed at evaluating the incidence of apoptotic features in human SCs. Primary cells were obtained from vastus lateralis of nine young (27.3±2.0 years old) and nine old (71.1±1.8 years old) subjects, and cultured in complete medium for analyses at 4, 24, 48, and 72 h. Apoptosis was assessed using AnnexinV/propidium iodide staining, the terminal deoxynucleotidyl transferase dUTP nick-end labelling technique, RT-PCR, DNA microarrays, flow cytometry, and immunofluorescence analysis. There was an increased rate of apoptotic cells in aged subjects at all of the experimental time points, with no direct correlation between AnnexinV-positive cells and caspase-8 activity. On the other hand, CASP2, CASP6, CASP7, and CASP9 and a number of cell death genes were upregulated in the aged SCs. Altogether, our data show age-related enhanced susceptibility of human SCs to apoptosis, which might be responsible for their reduced response to muscle damage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.