ArticleKidney international2014
Fructokinase activity mediates dehydration-induced renal injury.
Article in Kidney international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers, 2 of them syntheses that pooled it.
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Who cites it
110 citing papers in PubMed, 2 syntheses or guidelines pooled it, 266 citations in OpenAlex.
- Environmental risk factors for chronic kidney disease of non-traditional causes in tropical coastal areas: A systematic review and meta-analysis.PLoS neglected tropical diseases · 2025Pooled it
- Heat exposure and hospitalizations for chronic kidney disease in China: a nationwide time series study in 261 major Chinese cities.Military Medical Research · 2023Pooled it
- Hydrating with a higher-fructose sport drink does not worsen acute kidney injury risk during simulated work-related heat stress.American journal of physiology. Regulatory, integrative and comparative physiology · 2026Trial
- 24 h severe fluid restriction increases a biomarker of renal injury in healthy males.European journal of applied physiology · 2025Trial
- Trial
- Fructose increases risk for kidney stones: potential role in metabolic syndrome and heat stress.BMC nephrology · 2018Trial
- Increased Serum Sodium and Serum Osmolarity Are Independent Risk Factors for Developing Chronic Kidney Disease; 5 Year Cohort Study.PloS one · 2017Trial
- Epidemiology, mechanisms and clinical implications of heat-related kidney disease.Nature reviews. Nephrology · 2026Review
- Impact of recurrent dehydration with mild periodic water restriction on blood pressure and renal function in male spontaneously hypertensive rats.Experimental physiology · 2026Article
- Atmospheric stressors and kidney diseases.Nature reviews. Nephrology · 2026Review
- Fructose: metabolic signal and modern hazard.Nature metabolism · 2026Review
- Article
- Kidney organoids as a novel platform to evaluate heat-stress-induced acute kidney injury pathogenesis.Bioengineering & translational medicine · 2026Article
- Temporal trends in cross-country inequalities of chronic kidney disease attributable to temperature exposure from 1990 to 2021.International urology and nephrology · 2025Article
- Association of serum osmolality levels with all-cause mortality risk in patients with DKA.Scientific reports · 2025Observational
- Association between serum osmolality and chronic kidney disease prevalence: Evidence from NHANES 1999-2018.Scientific reports · 2025Article
- Estimating the Association Between Outdoor Temperature and Acute Kidney Injury Using Alternative Case Definitions.Journal of occupational and environmental medicine · 2025Article
- Heat-induced kidney disease: Understanding the impact.Journal of internal medicine · 2025Review
- Economic Analysis of a Rest-Shade-Hydration-Sanitation Program at a Nicaraguan Sugar Mill.Annals of global health · 2025Article
- Chronic Kidney Disease of Unknown Etiology: A Global Health Threat in Rural Agricultural Communities-Prevalence, Suspected Causes, Mechanisms, and Prevention Strategies.Pathophysiology : the official journal of the International Society for Pathophysiology · 2024Review
50 more citing papers are in PubMed but not listed here.
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Authors and funding
17 authors at 9 institutions in 4 countries.
Funding
Abstract
The epidemic of chronic kidney disease in Nicaragua (Mesoamerican nephropathy) has been linked with recurrent dehydration. Here we tested whether recurrent dehydration may cause renal injury by activation of the polyol pathway, resulting in the generation of endogenous fructose in the kidney that might subsequently induce renal injury via metabolism by fructokinase. Wild-type and fructokinase-deficient mice were subjected to recurrent heat-induced dehydration. One group of each genotype was provided water throughout the day and the other group was hydrated at night, after the dehydration. Both groups received the same total hydration in 24 h. Wild-type mice that received delayed hydration developed renal injury, with elevated serum creatinine, increased urinary NGAL, proximal tubular injury, and renal inflammation and fibrosis. This was associated with activation of the polyol pathway, with increased renal cortical sorbitol and fructose levels. Fructokinase-knockout mice with delayed hydration were protected from renal injury. Thus, recurrent dehydration can induce renal injury via a fructokinase-dependent mechanism, likely from the generation of endogenous fructose via the polyol pathway. Access to sufficient water during the dehydration period can protect mice from developing renal injury. These studies provide a potential mechanism for Mesoamerican nephropathy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.