Evidence map›Paper›PMID 24335922›Full record

ArticleBritish journal of cancer2014

Key differences identified between actinic keratosis and cutaneous squamous cell carcinoma by transcriptome profiling.

S R Lambert, N Mladkova, A Gulati, R Hamoudi, K Purdie, R Cerio, I Leigh, C Proby, C A Harwood

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 106 citations in OpenAlex.

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  14. Topical GZ21T Inhibits the Growth of Actinic Keratoses in a UVB-Induced Model of Skin Carcinogenesis.JID innovations : skin science from molecules to population health · 2023
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  16. TargetingFrontiers in oncology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

S R Lambert1] Centre for Cutaneous Research, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK [2] Cancer Research UK Skin Tumour Laboratory, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
N MladkovaCentre for Cutaneous Research, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
A GulatiCentre for Cutaneous Research, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
R HamoudiResearch Department of Pathology, Cancer Institute, Faculty of Medical Sciences, University College London, London WC1E 6BT, UK.
K Purdie1] Centre for Cutaneous Research, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK [2] Cancer Research UK Skin Tumour Laboratory, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
R CerioCentre for Cutaneous Research, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
I Leigh1] Cancer Research UK Skin Tumour Laboratory, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK [2] Skin Tumour Laboratory, Division of Cancer Research, Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK.
C Proby1] Cancer Research UK Skin Tumour Laboratory, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK [2] Skin Tumour Laboratory, Division of Cancer Research, Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK.
C A Harwood1] Centre for Cutaneous Research, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK [2] Cancer Research UK Skin Tumour Laboratory, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Queen Mary University of London · GBCancer Research UK · GBUniversity College London · GB

Funding

Cancer Research UK 13044
6 · The paper itself

Abstract

backgroundCutaneous squamous cell carcinoma (cSCC) is one of the most common malignancies in fair-skinned populations worldwide and its incidence is increasing. Despite previous observations of multiple genetic abnormalities in cSCC, the oncogenic process remains elusive. The purpose of this study was to elucidate key molecular events associated with progression from premalignant actinic keratoses (AKs) to invasive cSCC by transcriptome profiling.

methodsWe combined laser capture microdissection with the Affymetrix HGU133 Plus 2.0 microarrays to profile 30 cSCC and 10 AKs.

resultsWe identified a core set of 196 genes that are differentially expressed between AK and cSCC, and are enriched for processes including epidermal differentiation, cell migration, cell-cycle regulation and metabolism. Gene set enrichment analysis highlighted a key role for the mitogen activated protein kinase (MAPK) pathway in cSCC compared with AK. Furthermore, the histological subtype of the tumour was shown to influence the expression profile.

conclusionThese data indicate that the MAPK pathway may be pivotal to the transition from AK to cSCC, thus representing a potential target for cSCC prevention. In addition, transcriptome differences identified between cSCC subtypes have important implications for future development of targeted therapies for this malignancy.

Indexed as

AdultAgedAged, 80 and overCarcinoma, Squamous CellCell AdhesionCell CycleCell DifferentiationCell MovementCell ProliferationDisease ProgressionEpidermisFemaleGene Expression ProfilingHumansKeratosis, ActinicMaleMitogen-Activated Protein Kinases

Identifiers

PMID24335922
PMCPMC3899778
OpenAlexW2078982083

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.