ArticleBritish journal of cancer2014
Cigarette smoking, alcohol intake, and risk of glioma in the NIH-AARP Diet and Health Study.
Article in British journal of cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Modifiable risk factors for glioblastoma: a systematic review and meta-analysis.Neurosurgical review · 2023Pooled it
- Diet and risk of glioma: combined analysis of 3 large prospective studies in the UK and USA.Neuro-oncology · 2019Pooled it
- Pooled it
- Association of Daily Alcohol Consumption and Drinking Patterns with Risk of Primary Malignant Brain Tumor in Korean Adults: A Retrospective Cohort Study.Journal of cancer prevention · 2026Article
- Cyclodextrin-Based Formulations as a Promising Strategy to Overcome the Blood-Brain Barrier: Historical Overview and Prospects in Glioblastoma Treatment.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Latent Association Between Diets and Glioma Risk: A Mendelian Randomization Analysis.Nutrients · 2025Article
- Life-style and metabolic factors do not affect risk for glioma: a prospective population-based study (The Cohort of Norway).Frontiers in oncology · 2024Article
- Tobacco smoking associates with NF1 mutations exacerbating survival outcomes in gliomas.Biomarker research · 2022Article
- Beer, wine, and spirits differentially influence body composition in older white adults-a United Kingdom Biobank study.Obesity science & practice · 2022Article
- Alcohol intake and risk of pituitary adenoma.Cancer causes & control : CCC · 2022Article
- A combined healthy lifestyle score in relation to glioma: a case-control study.Nutrition journal · 2022Article
- Alcohol intake and risk of glioma: results from three prospective cohort studies.European journal of epidemiology · 2021Article
- The Influence of Gene Aberrations on Survival in ResectedCurrent oncology (Toronto, Ont.) · 2021Article
- Trends in Intracranial Glioma Incidence and Mortality in the United States, 1975-2018.Frontiers in oncology · 2021Article
- Assessment of Overall and Specific Cancer Risks in Patients With Hidradenitis Suppurativa.JAMA dermatology · 2020Article
- Cigarette Smoking Is Associated with Increased Risk of Malignant Gliomas: A Nationwide Population-Based Cohort Study.Cancers · 2020Article
- Risk factors for childhood and adult primary brain tumors.Neuro-oncology · 2019Review
- Genetic and molecular epidemiology of adult diffuse glioma.Nature reviews. Neurology · 2019Review
- Use of MendelianFrontiers in genetics · 2018Review
- Pre-diagnostic serum levels of EGFR and ErbB2 and genetic glioma risk variants: a nested case-control study.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAlthough cigarette smoking and alcohol drinking increase the risk of several cancers and certain components of cigarette smoke and alcohol can penetrate the blood-brain barrier, it remains unclear whether these exposures influence the risk of glioma.
methodsWe examined the associations between cigarette smoking, alcohol intake, and risk of glioma in the National Institutes of Health-AARP Diet and Health Study, a prospective study of 477,095 US men and women ages 50-71 years at baseline. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using models with age as the time metric and adjusted for sex, race/ethnicity, education, and marital status.
resultsDuring a median 10.5 person-years of follow-up, 492 men and 212 women were diagnosed with first primary glioma. Among men, current, heavier smoking was associated with a reduced risk of glioma compared with never smoking, but this was based on only nine cases. No associations were observed between smoking behaviours and glioma risk in women. Greater alcohol consumption was associated with a decreased risk of glioma, particularly among men (>2 drinks per day vs <1 drink per week: HR=0.67, 95% CI=0.51-0.90).
conclusionSmoking and alcohol drinking do not appear to increase the risk of glioma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.