ArticleThe ISME journal2014
Methanotrophic archaea possessing diverging methane-oxidizing and electron-transporting pathways.
Article in The ISME journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
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Who cites it
79 citing papers in PubMed, 180 citations in OpenAlex.
- Jumbo circular extrachromosomal elements of methane-oxidizing archaea with variably extensive metabolic and defense gene repertoires.Nature communications · 2026Article
- Marine Cold Seep ANME-2/SRB Consortia Produce Their Lipid Biomass From Inorganic Carbon.Environmental microbiology · 2025Article
- Exploring Energy Conservation in Sulphate-Dependent Anaerobic Methane-Oxidising Consortia Through Metabolic Modelling.Environmental microbiology · 2025Article
- Identification of key steps in the evolution of anaerobic methanotrophy inScience advances · 2025Article
- Unveiling the life of archaea in sediments: Diversity, metabolic potentials, and ecological roles.iMetaOmics · 2025Review
- Sulfide Toxicity as Key Control on Anaerobic Oxidation of Methane in Eutrophic Coastal Sediments.Environmental science & technology · 2024Article
- Phylogenetic diversity of functional genes in deep-sea cold seeps: a novel perspective on metagenomics.Microbiome · 2023Article
- The presence of benzene ring activating CoA ligases for aromatics degradation in the ANaerobic MEthanotrophic (ANME) archaea.Microbiology spectrum · 2023Article
- A comprehensive genomic catalog from global cold seeps.Scientific data · 2023Article
- Physiological potential and evolutionary trajectories of syntrophic sulfate-reducing bacterial partners of anaerobic methanotrophic archaea.PLoS biology · 2023Article
- Acetate and Acetyl-CoA Metabolism of ANME-2 Anaerobic Archaeal Methanotrophs.Applied and environmental microbiology · 2023Article
- An Initial Proteomic Analysis of Biogas-Related Metabolism ofMicroorganisms · 2023Article
- Composition and Metabolic Potential of Fe(III)-Reducing Enrichment Cultures of Methanotrophic ANME-2a Archaea and Associated Bacteria.Microorganisms · 2023Article
- Transcriptional and metabolomic responses ofFrontiers in microbiology · 2023Article
- A Reduced FJournal of bacteriology · 2022Article
- Meta-omics approaches reveal unique small RNAs exhibited by the uncultured microorganisms dwelling deep-sea hydrothermal sediment in Guaymas Basin.Archives of microbiology · 2022Article
- Article
- A Genome-Scale Metabolic Model ofMetabolites · 2022Article
- Deep-branching ANME-1c archaea grow at the upper temperature limit of anaerobic oxidation of methane.Frontiers in microbiology · 2022Article
- Sulfate differentially stimulates but is not respired by diverse anaerobic methanotrophic archaea.The ISME journal · 2022Article
19 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anaerobic oxidation of methane (AOM) is a crucial process limiting the flux of methane from marine environments to the atmosphere. The process is thought to be mediated by three groups of uncultivated methane-oxidizing archaea (ANME-1, 2 and 3). Although the responsible microbes have been intensively studied for more than a decade, central mechanistic details remain unresolved. On the basis of an integrated analysis of both environmental metatranscriptome and single-aggregate genome of a highly active AOM enrichment dominated by ANME-2a, we provide evidence for a complete and functioning AOM pathway in ANME-2a. All genes required for performing the seven steps of methanogenesis from CO2 were found present and actively expressed. Meanwhile, genes for energy conservation and electron transportation including those encoding F420H2 dehydrogenase (Fpo), the cytoplasmic and membrane-associated Coenzyme B-Coenzyme M heterodisulfide (CoB-S-SCoM) reductase (HdrABC, HdrDE), cytochrome C and the Rhodobacter nitrogen fixation (Rnf) complex were identified and expressed, whereas genes encoding for hydrogenases were absent. Thus, ANME-2a is likely performing AOM through a complete reversal of methanogenesis from CO2 reduction without involvement of canonical hydrogenase. ANME-2a is demonstrated to possess versatile electron transfer pathways that would provide the organism with more flexibility in substrate utilization and capacity for rapid adjustment to fluctuating environments. This work lays the foundation for understanding the environmental niche differentiation, physiology and evolution of different ANME subgroups.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.