Evidence map›Paper›PMID 24335762›Full record

Trial reportInternational journal of obesity (2005)2014

Ageing diminishes the modulation of human brain responses to visual food cues by meal ingestion.

Y S Cheah, S Lee, G Ashoor, Y Nathan, L J Reed, F O Zelaya, M J Brammer, S A Amiel

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in International journal of obesity (2005), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 20 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Y S CheahDiabetes Research Group, School of Medicine, King's College London, London, UK.
S Lee1] Diabetes Research Group, School of Medicine, King's College London, London, UK [2] Centre for Neuroimaging Sciences, Institute of Psychiatry, King's College London, London, UK.
G AshoorDiabetes Research Group, School of Medicine, King's College London, London, UK.
Y NathanDiabetes Research Group, School of Medicine, King's College London, London, UK.
L J Reed1] Centre for Neuroimaging Sciences, Institute of Psychiatry, King's College London, London, UK [2] Division of Brain Sciences, Centre for Mental Health, Imperial College London, London, UK.
F O ZelayaCentre for Neuroimaging Sciences, Institute of Psychiatry, King's College London, London, UK.
M J BrammerCentre for Neuroimaging Sciences, Institute of Psychiatry, King's College London, London, UK.
S A AmielDiabetes Research Group, School of Medicine, King's College London, London, UK.
King's College London · GBWellcome Centre for Human Neuroimaging · GB

Funding

Department of HealthMedical Research Council MR/J006742/1
6 · The paper itself

Abstract

BACKGROUND/

objectivesRates of obesity are greatest in middle age. Obesity is associated with altered activity of brain networks sensing food-related stimuli and internal signals of energy balance, which modulate eating behaviour. The impact of healthy mid-life ageing on these processes has not been characterised. We therefore aimed to investigate changes in brain responses to food cues, and the modulatory effect of meal ingestion on such evoked neural activity, from young adulthood to middle age. SUBJECTS/

methodsTwenty-four healthy, right-handed subjects, aged 19.5-52.6 years, were studied on separate days after an overnight fast, randomly receiving 50 ml water or 554 kcal mixed meal before functional brain magnetic resonance imaging while viewing visual food cues.

resultsAcross the group, meal ingestion reduced food cue-evoked activity of amygdala, putamen, insula and thalamus, and increased activity in precuneus and bilateral parietal cortex. Corrected for body mass index, ageing was associated with decreasing food cue-evoked activation of right dorsolateral prefrontal cortex (DLPFC) and precuneus, and increasing activation of left ventrolateral prefrontal cortex (VLPFC), bilateral temporal lobe and posterior cingulate in the fasted state. Ageing was also positively associated with the difference in food cue-evoked activation between fed and fasted states in the right DLPFC, bilateral amygdala and striatum, and negatively associated with that of the left orbitofrontal cortex and VLPFC, superior frontal gyrus, left middle and temporal gyri, posterior cingulate and precuneus. There was an overall tendency towards decreasing modulatory effects of prior meal ingestion on food cue-evoked regional brain activity with increasing age.

conclusionsHealthy ageing to middle age is associated with diminishing sensitivity to meal ingestion of visual food cue-evoked activity in brain regions that represent the salience of food and direct food-associated behaviour. Reduced satiety sensing may have a role in the greater risk of obesity in middle age.

Indexed as

Appetite RegulationCuesEatingFoodAdultAgingAppetiteBrainFastingFemaleHumansMaleMiddle AgedObesityPhotic StimulationSatiation

Identifiers

PMID24335762
OpenAlexW2068166904

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.