Evidence map›Paper›PMID 24335706›Full record

ArticleGenes and immunity2014

Idd13 is involved in determining immunoregulatory DN T-cell number in NOD mice.

V Dugas, A Liston, E E Hillhouse, R Collin, G Chabot-Roy, A-N Pelletier, C Beauchamp, K Hardy, S Lesage

Erratum issuedAbstract read
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In one paragraph

Article in Genes and immunity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. (TCRαβCells · 2025
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4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

9 authors.

V Dugas1] Research Center, Immunology-Oncology Section, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada [2] Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, Quebec, Canada.
A ListonAutoimmune Genetics Laboratory, Department of Microbiology and Immunology, VIB and University of Leuven, Leuven, Belgium.
E E Hillhouse1] Research Center, Immunology-Oncology Section, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada [2] Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, Quebec, Canada.
R Collin1] Research Center, Immunology-Oncology Section, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada [2] Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, Quebec, Canada.
G Chabot-RoyResearch Center, Immunology-Oncology Section, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada.
A-N Pelletier1] Research Center, Immunology-Oncology Section, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada [2] Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, Quebec, Canada.
C Beauchamp1] Research Center, Immunology-Oncology Section, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada [2] Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, Quebec, Canada.
K HardyDivision of Biomedical Sciences, University of Canberra, Bruce, Canberra, Australia.
S Lesage1] Research Center, Immunology-Oncology Section, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada [2] Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, Quebec, Canada.

Funding

Canadian Institutes of Health Research
6 · The paper itself

Abstract

Immunoregulatory T cells have been identified as key modulators of peripheral tolerance and participate in preventing autoimmune diseases. CD4(-)CD8(-) (double negative, DN) T cells compose one of these immunoregulatory T-cell subsets, where the injection of DN T cells confers protection from autoimmune diabetes progression. Interestingly, genetic loci defining the function and number of CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs) coincide with at least some autoimmune disease susceptibility loci. Herein, we investigate the impact of major insulin-dependent diabetes (Idd) loci in defining the number of DN T cells. We demonstrate that although Idd3, Idd5 and Idd9 loci do not regulate DN T-cell number, NOD mice congenic for diabetes resistance alleles at the Idd13 locus show a partial restoration in DN T-cell number. Moreover, competitive and non-competitive bone marrow chimera experiments reveal that DN T-cell number is defined by a bone marrow-intrinsic, but DN T-cell-extrinsic, factor. This suggests that non-autonomous candidate genes define DN T-cell number in secondary lymphoid organs. Together, our results show that the regulation of DN T-cell number in NOD mice is at least partially conferred by alleles at the Idd13 locus.

Indexed as

AnimalsCD4 AntigensCD8 AntigensDiabetes Mellitus, Type 1Genetic Predisposition to DiseaseLymphocyte CountMiceMice, Inbred C57BLMice, Inbred CBAMice, Inbred NODMice, TransgenicPeripheral ToleranceT-Lymphocyte SubsetsCD4 AntigensCD8 Antigens

Identifiers

PMID24335706

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.