ArticleNature cell biology2014
Stem cell quiescence acts as a tumour suppressor in squamous tumours.
Article in Nature cell biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 74 citations in OpenAlex.
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- Defining metabolic flexibility in hair follicle stem cell induced squamous cell carcinoma.Science advances · 2024Article
- How much do we know about the metastatic process?Clinical & experimental metastasis · 2024Review
- Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation.Nature cell biology · 2024Article
- The journey from melanocytes to melanoma.Nature reviews. Cancer · 2023Review
- Review
- MicroRNA-205 promotes hair regeneration by modulating mechanical properties of hair follicle stem cells.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Diet suppresses glioblastoma initiation in mice by maintaining quiescence of mutation-bearing neural stem cells.Developmental cell · 2023Article
- RAS oncogene signal strength regulates matrisomal gene expression and tumorigenicity of mouse keratinocytes.Carcinogenesis · 2022Article
- Basal cell carcinomas acquire secondary mutations to overcome dormancy and progress from microscopic to macroscopic disease.Cell reports · 2022Article
- Defining a Role for G-Protein Coupled Receptor/cAMP/CRE-Binding Protein Signaling in Hair Follicle Stem Cell Activation.The Journal of investigative dermatology · 2022Article
- Polycomb repressive complex 2 in adult hair follicle stem cells is dispensable for hair regeneration.PLoS genetics · 2021Article
- A stress-induced miR-31-CLOCK-ERK pathway is a key driver and therapeutic target for skin aging.Nature aging · 2021Article
- DAF-18/PTEN inhibits germline zygotic gene activation during primordial germ cell quiescence.PLoS genetics · 2021Article
- Effects of UV Induced-Photoaging on the Hair Follicle Cycle of C57BL6/J Mice.Clinical, cosmetic and investigational dermatology · 2021Article
- Its written all over your face: The molecular and physiological consequences of aging skin.Mechanisms of ageing and development · 2020Review
- Phenotypic Plasticity of Cutaneous Squamous Cell Carcinoma Mediated by Cyclooxygenase-2.The Journal of investigative dermatology · 2020Article
- OncogenicLife science alliance · 2020Article
- New insights into the functions of Cox-2 in skin and esophageal malignancies.Experimental & molecular medicine · 2020Review
- Wnt Signaling Pathways in Keratinocyte Carcinomas.Cancers · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
In some organs, adult stem cells are uniquely poised to serve as cancer cells of origin. It is unclear, however, whether tumorigenesis is influenced by the activation state of the adult stem cell. Hair follicle stem cells (HFSCs) act as cancer cells of origin for cutaneous squamous cell carcinoma and undergo defined cycles of quiescence and activation. The data presented here show that HFSCs are unable to initiate tumours during the quiescent phase of the hair cycle, indicating that the mechanisms that keep HFSCs dormant are dominant over the gain of oncogenes (such as Ras) or the loss of tumour suppressors (such as p53). Furthermore, Pten activity is necessary for quiescence-based tumour suppression, as its deletion alleviates tumour suppression without affecting proliferation. These data demonstrate that stem cell quiescence is a form of tumour suppression in HFSCs, and that Pten plays a role in maintaining quiescence in the presence of tumorigenic stimuli.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.