ArticleJournal of the Royal Society, Interface2014
Calcium waves initiating from the anomalous subdiffusive calcium sparks.
Article in Journal of the Royal Society, Interface, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- A stochastic mathematical model for coupling the cytosolic and sarcoplasmic calcium movements in diseased cardiac myocytes.European biophysics journal : EBJ · 2022Article
- Cardiac Alternans Occurs through the Synergy of Voltage- and Calcium-Dependent Mechanisms.Membranes · 2021Article
- Effects of rogue ryanodine receptors on CaRoyal Society open science · 2018Article
- The Interplay of Rogue and Clustered Ryanodine Receptors Regulates CaFrontiers in physiology · 2018Article
- Studying dyadic structure-function relationships: a review of current modeling approaches and new insights into CaClinical Medicine Insights. Cardiology · 2017Article
- Remodeling of left circumflex coronary arterial tree in pacing-induced heart failure.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Estimation of stochastic behaviour in cardiac myocytes: I. CaJRSM cardiovascular diseaseArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of the study is to investigate the propagation of Ca(2+) waves in full-width cardiac myocytes and carry out sensitivity analysis to study the effects of various physiological parameters on global Ca(2+) waves. Based on the anomalous subdiffusion of Ca(2+) sparks, a mathematical model was proposed to characterize the Ca(2+) waves. The computed results were in agreement with the experimental measurements using confocal microscopy. This model includes variables of current through the Ca(2+) release unit (CRU; ICRU), duration of current flow through CRU (Topen), Ca(2+) sensitivity parameter (K), the longitudinal and transverse spatial separation of CRUs (lx and ly, where x denotes longitudinal direction (x-axis) and y denotes transverse direction (y-axis)) and Ca(2+) diffusion coefficients (Dx, Dy). The spatio-temporal mechanism of the anomalous Ca(2+) sparks led to results that were different from those based on Fick's law. The major findings were reported as: ICRU affected the dynamic properties of Ca(2+) waves more significantly than Topen; the effect of K on the properties of Ca(2+) waves was negligible; ly affected the amplitude significantly, but lx affected the longitudinal velocity significantly; in turn, the limitation and significance of the study are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.