ArticleAmerican journal of nephrology2013
Prevalence and correlates of fatigue in chronic kidney disease and end-stage renal disease: are sleep disorders a key to understanding fatigue?
Article in American journal of nephrology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 4 of them syntheses that pooled it.
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Who cites it
71 citing papers in PubMed, 4 syntheses or guidelines pooled it, 139 citations in OpenAlex.
- Carnitine supplements for people with chronic kidney disease requiring dialysis.The Cochrane database of systematic reviews · 2022Pooled it
- The impact of change of renal replacement therapy modality on sleep quality in patients with end-stage renal disease: a systematic review and meta-analysis.Journal of nephrology · 2018Pooled it
- Efficiency of bimaxillary advancement surgery in increasing the volume of the upper airways: a systematic review of observational studies and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017Pooled it
- Pharmacological treatments for fatigue associated with palliative care.The Cochrane database of systematic reviews · 2015Pooled it
- Effects of progressive muscle relaxation exercises on the vital signs and fatigue in kidney transplant patients: a randomized controlled trial.International urology and nephrology · 2024Trial
- Utilizing technology for diet and exercise change in complex chronic conditions across diverse environments (U-DECIDE): feasibility randomised controlled trial.BMC health services research · 2024Trial
- Design and Baseline Characteristics of CONCORD, a Trial of Novel Therapies for Depression in CKD.Kidney international reports · 2026Article
- Sleep Hygiene Among People With CKD.Kidney international reports · 2026Article
- Muscle strength, neuromuscular function, and functional measures across stages of chronic kidney disease.BMC nephrology · 2026Article
- Risk Factors for Fatigue in Adults Receiving Maintenance Hemodialysis Who Have Chronic Pain: A Secondary Analysis of the HOPE Consortium Trial.Kidney medicine · 2026Article
- Fatigue and Related Sleep Disturbances in Hemodialysis Patients: Prevalence, Associated Factors, and the Influence of Nutritional Status.Nutrients · 2025Article
- Sleep-Related Disorders in Patients with CKD and Kidney Transplant Recipients.Clinical journal of the American Society of Nephrology : CJASN · 2025Review
- Fatigue across different chronic kidney disease populations: experiences and needs of patients.Clinical kidney journal · 2025Article
- Insights into effective fatigue reducing interventions in kidney transplant candidates: a scoping review.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2025Article
- Fatigue and quality of sleep jointly influence the association between physical activity and health-related quality of life in patients with chronic kidney disease: a cross-sectional study.Frontiers in nephrology · 2025Article
- Associations Between Fatigue and Cardiovascular-Kidney-Metabolic Syndrome and the Mediating Role of Inflammation.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Translation, cultural adaptation, and validation of the Chinese standardized outcomes in nephrology-hemodialysis fatigue (C-SONG-HD fatigue) scale: a study of Chinese patients undergoing hemodialysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Article
- Comparing the effect of warmwater footbath with effleurage and petrissage massages on fatigue of patients undergoing hemodialysis.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2024Article
- Article
- Factors associated with subgroups of fatigue in maintenance hemodialysis patients: a cross-sectional study.Renal failure · 2023Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundFatigue is an important symptom to patients with advanced chronic kidney disease (CKD). The aim of this study is to examine the prevalence and severity of fatigue among non-dialysis-dependent CKD and end-stage renal disease (ESRD) patients, to examine the association of fatigue with subjective and objective sleep quality, and to identify other modifiable factors associated with fatigue.
methodsA cross-sectional survey of 87 non-dialysis-dependent CKD (eGFR ≤45 ml/min/1.73 m(2)) and 86 ESRD patients was done using the Functional Assessment of Chronic Illness Therapy - Fatigue (FACIT-F) and 36-Item Short-Form (SF-36) vitality scale. Higher FACIT-F score denoted less fatigue. Objective sleep was assessed using in-home polysomnography. Predictors of fatigue were determined using a linear regression model.
resultsThe mean FACIT-F score among all participants was 34.5 ± 11.0. Mean scores were similar among CKD and ESRD groups (34.25 ± 11.28 vs. 34.73 ± 10.86; p = 0.73). On univariate analyses, patients with higher levels of fatigue were more likely to have cardiovascular disease, benzodiazepine use, depressive symptoms, and slightly lower hemoglobin and serum albumin levels. There was no significant association between severity of sleep apnea and level of fatigue (Apnea Hypopnea Index 20.1 ± 27.6 vs. 20.3 ± 22.0; p = 0.69). Presence of cardiovascular disease, low serum albumin, depressive symptoms, poor subjective sleep quality, excessive daytime sleepiness and restless legs syndrome were independently associated with greater fatigue in multivariable regression models. The FACIT-F score correlated closely with the SF-36 vitality score (r = 0.81, p < 0.0001).
conclusionsPatients with advanced CKD and ESRD experience profound fatigue. Depressive symptoms, restless legs syndrome, excessive daytime sleepiness, and low albumin levels may provide targets for interventions to improve fatigue in patients with advanced CKD.
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