ArticleJournal of neurophysiology2014
Reorganization of hippocampal functional connectivity with transition to chronic back pain.
Article in Journal of neurophysiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 1 of them a synthesis that pooled it.
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Who cites it
100 citing papers in PubMed, 1 synthesis or guideline pooled it, 184 citations in OpenAlex.
- The medial temporal lobe in nociception: a meta-analytic and functional connectivity study.Pain · 2019Pooled it
- A randomized placebo-controlled pilot study of the efficacy and safety of D-cycloserine in people with chronic back pain.Molecular pain · 2016Trial
- Altered hippocampal subfield functional connectivity and its association with back pain in axial spondyloarthritis: a multimodal neuroimaging study.Brain imaging and behavior · 2026Article
- Brain dysconnectivity patterns associated with chronic back pain development.Brain informatics · 2026Article
- Chronic ocular pain is associated with smaller selective hippocampal subfield in highly symptomatic patients.The journal of pain · 2026Article
- 40 Hz light flickering alleviates chronic pain via adenosine signaling in the retina-amygdala pathway.Cell research · 2026Article
- Article
- Affective tactile stimulation ameliorates chronic pain and comorbid anxiety by modulating hippocampal CA1 oscillations and functional connectivity.Frontiers in molecular neuroscience · 2026Article
- Precision connectivity in osteoarthritis pain with permutation and network analysis: a key step toward clinical application.BMC medical imaging · 2025Article
- Selective vulnerability of GABAergic neurons in chronic migraine.The journal of headache and pain · 2025Article
- Volumetric analysis of hippocampal subregions in migraine without aura: an exploratory study on mechanisms underlying migraine chronification.The journal of headache and pain · 2025Article
- Article
- Electroacupuncture Ameliorates Chronic Inflammatory Pain and Depression Comorbidity by Inhibiting Nrf2-Mediated Ferroptosis in Hippocampal Neurons.Neurochemical research · 2025Article
- Temporal lobe dysfunction for comorbid depressive symptoms in postherpetic neuralgia patients.Brain communications · 2025Article
- Hippocampal Functional Radiomic Features for Identification of the Cognitively Impaired Patients from Low-Back-Related Pain: A Prospective Machine Learning Study.Journal of pain research · 2025Article
- Chronic Pain-Related Cognitive Deficits: Preclinical Insights into Molecular, Cellular, and Circuit Mechanisms.Molecular neurobiology · 2024Review
- A neural circuit for alcohol withdrawal-induced hyperalgesia in a nondependent state.Science advances · 2024Article
- Article
- Individuals With Prior Chronic Pain and Long-Term Opioid Treatment May Experience Persistence of That Pain Even After Subsequent Complete Cervical Spinal Cord Injury: Suggestions From a Prospective Case-Controlled Study.Archives of rehabilitation research and clinical translation · 2024Article
- Ventral Hippocampal CA1 Pyramidal Neurons Encode Nociceptive Information.Neuroscience bulletin · 2024Article
40 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
The hippocampus has been shown to undergo significant changes in rodent models of neuropathic pain; however, the role of the hippocampus in human chronic pain and its contribution to pain chronification have remained unexplored. Here we examine hippocampal processing during a simple visual attention task. We used functional MRI to identify intrinsic and extrinsic hippocampal functional connectivity (synchronous neural activity), comparing subacute back pain (SBP, back pain 1-4 mo) and chronic back pain (CBP, back pain >10 yr) patients to control (CON) subjects. Both groups showed more extensive hippocampal connectivity than CON subjects. We then examined the evolution of hippocampal connectivity longitudinally in SBP patients who recovered (SBPr, back pain decreased >20% in 1 yr) and those with persistent pain (SBPp). We found that SBPp and SBPr subjects have distinct changes in hippocampal-cortical connectivity over 1 yr; specifically, SBPp subjects showed large decreases in hippocampal connectivity with medial prefrontal cortex (HG-mPFC). Furthermore, in SBP patients the strength of HG-mPFC reflected variations in back pain over the year. These relationships were replicated when examined in a different task performed by SBP patients (rating fluctuations of back pain), indicating that functional connectivity of the hippocampus changes robustly in subacute pain and the nature of these changes depends on whether or not patients recover from SBP. The observed reorganization of processing within the hippocampus and between the hippocampus and the cortex seems to contribute to the transition from subacute to chronic pain and may also underlie learning and emotional abnormalities associated with chronic pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.