Trial reportThe American journal of clinical nutrition2014
Variants in glucose- and circadian rhythm-related genes affect the response of energy expenditure to weight-loss diets: the POUNDS LOST Trial.
Trial report in The American journal of clinical nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 31 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Preventing Overweight Using Novel Dietary Strategies (Pounds Lost)
Effect of Combined Physical Training At Different Times of the Day on Muscle and Adipose Tissue Remodeling, Metabolism and Physical Performance in Female Mice and Women with Obesity
Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Food Intake According to Clock Gene Polymorphisms: A Systematic Review.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Pooled it
- Reduction in saturated fat intake for cardiovascular disease.The Cochrane database of systematic reviews · 2020Pooled it
- Reduction in saturated fat intake for cardiovascular disease.The Cochrane database of systematic reviews · 2020Pooled it
- MTNR1B genotype and effects of carbohydrate quantity and dietary glycaemic index on glycaemic response to an oral glucose load: the OmniCarb trial.Diabetologia · 2024Trial
- Macronutrient-specific effect of theJournal of lipid research · 2018Trial
- Markers of dietary protein intake are associated with successful weight loss in the POUNDS Lost trial.Clinical obesity · 2017Trial
- Clock Gene Variants Are Associated with Energy and Macronutrient Intake in Early Childhood and Adulthood.Nutrients · 2026Article
- A Bibliometric Study from 1992 to 2023 on the Relationship between Biological Clock and Diabetes.Endocrine, metabolic & immune disorders drug targets · 2025Article
- Article
- Circadian Gene Variants in Diseases.Genes · 2023Review
- Toward Precision Weight-Loss Dietary Interventions: Findings from the POUNDS Lost Trial.Nutrients · 2023Review
- NAMPT-dependent NADProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Genetically-Guided Medical Nutrition Therapy in Type 2 Diabetes Mellitus and Pre-diabetes: A Series ofFrontiers in nutrition · 2022Article
- The effect of heteroscedasticity on the prediction efficiency of genome-wide polygenic score for body mass index.Frontiers in genetics · 2022Article
- Circadian rhythms and pancreas physiology: A review.Frontiers in endocrinology · 2022Review
- Variants of the cry 1 gene may influence the effect of fat intake on resting metabolic rate in women with overweight of obesity: a cross-sectional study.BMC endocrine disorders · 2021Article
- Sex-Specific Associations between Gut Prevotellaceae and Host Genetics on Adiposity.Microorganisms · 2020Article
- Contribution of macronutrients to obesity: implications for precision nutrition.Nature reviews. Endocrinology · 2020Review
- Combined administration of exogenous melatonin and insulin ameliorates streptozotocin induced toxic alteration on hematological parameters in diabetic male Wistar rats.Toxicology reports · 2020Article
- Lessons Learned from the POUNDS Lost Study: Genetic, Metabolic, and Behavioral Factors Affecting Changes in Body Weight, Body Composition, and Cardiometabolic Risk.Current obesity reports · 2019Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCircadian rhythm has been shown to be related to glucose metabolism and risk of diabetes, probably through effects on energy balance. Recent genome-wide association studies identified variants in circadian rhythm-related genes (CRY2 and MTNR1B) associated with glucose homeostasis.
objectiveWe tested whether CRY2 and MTNR1B genotypes affected changes in measures of energy expenditure in response to a weight-loss diet intervention in a 2-y randomized clinical trial, the POUNDS (Preventing Overweight Using Novel Dietary Strategies) LOST Trial.
designThe variants CRY2 rs11605924 (n = 721) and MTNR1B rs10830963 (n = 722) were genotyped in overweight or obese adults who were randomly assigned to 1 of 4 weight-loss diets that differed in their proportions of macronutrients. Respiratory quotient (RQ) and resting metabolic rate (RMR) were measured.
resultsBy 2 y of diet intervention, the A allele of CRY2 rs11605924 was significantly associated with a greater reduction in RQ (P = 0.03) and a greater increase in RMR and RMR/kg (both P = 0.04). The G allele of MTNR1B rs10830963 was significantly associated with a greater increase in RQ (P = 0.01) but was not related to changes in RMR and RMR/kg. In addition, we found significant gene-diet fat interactions for both CRY2 (P-interaction = 0.02) and MTNR1B (P-interaction < 0.001) in relation to 2-y changes in RQ.
conclusionsOur data indicate that variants in the circadian-related genes CRY2 and MTNR1B may affect long-term changes in energy expenditure, and dietary fat intake may modify the genetic effects. This trial was registered at www.clinicaltrials.gov as NCT00072995.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.