ArticleNucleic acids research2014
Compromised telomere maintenance in hypomethylated Arabidopsis thaliana plants.
Article in Nucleic acids research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- DDM1-mediated R-loop resolution and H2A.Z exclusion facilitates heterochromatin formation in Arabidopsis.Science advances · 2023Article
- Epigenetic nature of Arabidopsis thaliana telomeres.Plant physiology · 2023Article
- Genome-wide characterization of i-motifs and their potential roles in the stability and evolution of transposable elements in rice.Nucleic acids research · 2022Article
- A complex network of interactions governs DNA methylation at telomeric regions.Nucleic acids research · 2022Article
- Relative Telomere Length and Telomerase Reverse Transcriptase (TERT) Expression Are Associated with Age in Almond (Plants (Basel, Switzerland) · 2021Article
- Distinct Responses of Arabidopsis Telomeres and Transposable Elements to Zebularine Exposure.International journal of molecular sciences · 2021Article
- Telomeres and Subtelomeres Dynamics in the Context of Early Chromosome Interactions During Meiosis and Their Implications in Plant Breeding.Frontiers in plant science · 2021Review
- The epigenetic regulation of centromeres and telomeres in plants and animals.Comparative cytogenetics · 2020Review
- Review
- Telomere elongation upon transfer to callus culture reflects the reprogramming of telomere stability control in Arabidopsis.Plant molecular biology · 2018Article
- DDM1 guards against telomere truncation in Arabidopsis.Plant cell reports · 2018Article
- Novel features of telomere biology revealed by the absence of telomeric DNA methylation.Genome research · 2016Article
- Determination of Arabidopsis thaliana telomere length by PCR.Scientific reports · 2014Article
- MAGI: Methylation analysis using genome information.Epigenetics · 2014Article
- Plant chromatin warms up in Madrid: meeting summary of the 3rd European Workshop on Plant Chromatin 2013, Madrid, Spain.Epigenetics · 2014Article
- Chromatin features of plant telomeric sequences at terminal vs. internal positions.Frontiers in plant science · 2014Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Telomeres, nucleoprotein structures at the ends of linear eukaryotic chromosomes, are important for the maintenance of genomic stability. Telomeres were considered as typical heterochromatic regions, but in light of recent results, this view should be reconsidered. Asymmetrically located cytosines in plant telomeric DNA repeats may be substrates for a DNA methyltransferase enzyme and indeed, it was shown that these repeats are methylated. Here, we analyse the methylation of telomeric cytosines and the length of telomeres in Arabidopsis thaliana methylation mutants (met 1-3 and ddm 1-8), and in their wild-type siblings that were germinated in the presence of hypomethylation drugs. Our results show that cytosine methylation in telomeric repeats depends on the activity of MET1 and DDM1 enzymes. Significantly shortened telomeres occur in later generations of methylation mutants as well as in plants germinated in the presence of hypomethylation drugs, and this phenotype is stably transmitted to the next plant generation. A possible role of compromised in vivo telomerase action in the observed telomere shortening is hypothesized based on telomere analysis of hypomethylated telomerase knockout plants. Results are discussed in connection with previous data in this field obtained using different model systems.
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