ArticleInfection control and hospital epidemiology2014
A mathematical model to evaluate the routine use of fecal microbiota transplantation to prevent incident and recurrent Clostridium difficile infection.
Article in Infection control and hospital epidemiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Article
- Examining the impact of ICU population interaction structure on modeled colonization dynamics of Staphylococcus aureus.PLoS computational biology · 2022Article
- A review of epidemiological models of Clostridioides difficile transmission and control (2009-2021).Anaerobe · 2022Review
- Computational approaches to understanding Clostridioides difficile metabolism and virulence.Current opinion in microbiology · 2022Review
- Article
- Estimated Methicillin-Resistant Staphylococcus aureus Decolonization in Intensive Care Units Associated With Single-Application Chlorhexidine Gluconate or Mupirocin.JAMA network open · 2021Article
- Anti-toxin antibody is not associated with recurrent Clostridium difficile infection.Anaerobe · 2021Article
- Article
- Fast and near-optimal monitoring for healthcare acquired infection outbreaks.PLoS computational biology · 2019Article
- Estimating the impact post randomization changes in staff behavior in infection prevention trials: a mathematical modeling approach.BMC infectious diseases · 2017Article
- Probiotics for Prevention of Clostridium difficile Infection in Hospitalized Patients: Is the Jury Still Out?Gastroenterology · 2017Article
- Epidemiology, Diagnosis, and Management of Clostridium difficile Infection in Patients with Inflammatory Bowel Disease.Inflammatory bowel diseases · 2016Review
- The human microbiota: novel targets for hospital-acquired infections and antibiotic resistance.Annals of epidemiology · 2016Review
- Quantifying Transmission of Clostridium difficile within and outside Healthcare Settings.Emerging infectious diseases · 2016Article
- Fecal microbiota transplantation for the treatment of Clostridium difficile infection.Journal of hospital medicine · 2016Review
- Dramatic reduction in Clostridium difficile ribotype 027-associated mortality with early fecal transplantation by the nasogastric route: a preliminary report.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015Article
- Fecal microbiota transplantation for the management of Clostridium difficile infection.Infectious disease clinics of North America · 2015Review
- Article
- Fecal microbiota therapy: ready for prime time?Infection control and hospital epidemiology · 2014Article
- Article
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Abstract
objectiveFecal microbiota transplantation (FMT) has been suggested as a new treatment to manage Clostridium difficile infection (CDI). With use of a mathematical model of C. difficile within an intensive care unit (ICU), we examined the potential impact of routine FMT. DESIGN, SETTING, AND PATIENTS: A mathematical model of C. difficile transmission, supplemented with prospective cohort, surveillance, and billing data from hospitals in the southeastern United States.
methodsCohort, surveillance, and billing data as well as data from the literature were used to construct a compartmental model of CDI within an ICU. Patients were defined as being in 1 of 6 potential health states: uncolonized and at low risk; uncolonized and at high risk; colonized and at low risk; colonized and at high risk; having CDI; or treated with FMT.
resultsThe use of FMT to treat patients after CDI was associated with a statistically significant reduction in recurrence but not with a reduction in incident cases. Treatment after administration of high-risk medications, such as antibiotics, did not result in a decrease in recurrence but did result in a statistically significant difference in incident cases across treatment groups, although whether this difference was clinically relevant was questionable.
conclusionsOur study is a novel mathematical model that examines the effect of FMT on the prevention of recurrent and incident CDI. The routine use of FMT represents a promising approach to reduce complex recurrent cases, but a reduction in CDI incidence will require the use of other methods to prevent transmission.
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