ArticlePhysics in medicine and biology2014
Direct dose mapping versus energy/mass transfer mapping for 4D dose accumulation: fundamental differences and dosimetric consequences.
Article in Physics in medicine and biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Dose Mapping and Accumulation for Re-Irradiation of Lung Cancers: Methodological Principles, Uncertainties, Quality Assurance, and Practical Clinical Considerations.Journal of clinical medicine · 2026Review
- Real-Time Dose-Guided Radiation Therapy.International journal of radiation oncology, biology, physics · 2025Review
- Pelvic dose accumulation accuracy in a CBCT based online adaptive radiotherapy system.Journal of applied clinical medical physics · 2025Article
- Monte Carlo dose calculation for photon and electron radiotherapy on dynamically deforming anatomy.Medical physics · 2025Article
- An energy-conserving dose summation method for dose accumulation in radiotherapy.Medical physics · 2025Article
- A multi-institutional comparison of retrospective deformable dose accumulation for online adaptive magnetic resonance-guided radiotherapy.Physics and imaging in radiation oncology · 2024Article
- Article
- Applicability and usage of dose mapping/accumulation in radiotherapy.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2023Review
- Development of a multi-layer quality assurance program to evaluate the uncertainty of deformable dose accumulation in adaptive radiotherapy.Medical physics · 2023Article
- Towards mid-position based Stereotactic Body Radiation Therapy using online magnetic resonance imaging guidance for central lung tumours.Physics and imaging in radiation oncology · 2022Article
- Dose accumulation for MR-guided adaptive radiotherapy: From practical considerations to state-of-the-art clinical implementation.Frontiers in oncology · 2022Review
- Adaptive Radiation Therapy (ART) Strategies and Technical Considerations: A State of the ART Review From NRG Oncology.International journal of radiation oncology, biology, physics · 2021Review
- On the determination of planning target margins due to motion for mice lung tumours using a four-dimensional MOBY phantom.The British journal of radiology · 2019Article
- The effect of density overrides on magnetic resonance-guided radiation therapy planning for lung cancer.Physics and imaging in radiation oncology · 2018Article
- Real-time energy/mass transfer mapping for online 4D dose reconstruction.Scientific reports · 2018Article
- Adaptive radiotherapy for NSCLC patients: utilizing the principle of energy conservation to evaluate dose mapping operations.Physics in medicine and biology · 2017Article
- Evaluation of Dosimetric Robustness of Carbon Ion Boost Therapy for Anal Carcinoma.International journal of particle therapy · 2017Article
- Real-time 4D dose reconstruction for tracked dynamic MLC deliveries for lung SBRT.Medical physics · 2016Article
- A critical review of recent developments in radiotherapy for non-small cell lung cancer.Radiation oncology (London, England) · 2016Review
- Improving radiotherapy planning, delivery accuracy, and normal tissue sparing using cutting edge technologies.Journal of thoracic disease · 2014Review
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7 authors.
Funding
Abstract
The direct dose mapping (DDM) and energy/mass transfer (EMT) mapping are two essential algorithms for accumulating the dose from different anatomic phases to the reference phase when there is organ motion or tumor/tissue deformation during the delivery of radiation therapy. DDM is based on interpolation of the dose values from one dose grid to another and thus lacks rigor in defining the dose when there are multiple dose values mapped to one dose voxel in the reference phase due to tissue/tumor deformation. On the other hand, EMT counts the total energy and mass transferred to each voxel in the reference phase and calculates the dose by dividing the energy by mass. Therefore it is based on fundamentally sound physics principles. In this study, we implemented the two algorithms and integrated them within the Eclipse treatment planning system. We then compared the clinical dosimetric difference between the two algorithms for ten lung cancer patients receiving stereotactic radiosurgery treatment, by accumulating the delivered dose to the end-of-exhale (EE) phase. Specifically, the respiratory period was divided into ten phases and the dose to each phase was calculated and mapped to the EE phase and then accumulated. The displacement vector field generated by Demons-based registration of the source and reference images was used to transfer the dose and energy. The DDM and EMT algorithms produced noticeably different cumulative dose in the regions with sharp mass density variations and/or high dose gradients. For the planning target volume (PTV) and internal target volume (ITV) minimum dose, the difference was up to 11% and 4% respectively. This suggests that DDM might not be adequate for obtaining an accurate dose distribution of the cumulative plan, instead, EMT should be considered.
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