Evidence map›Paper›PMID 24334139›Full record

ArticleCancer letters2014

H460 non-small cell lung cancer stem-like holoclones yield tumors with increased vascularity.

Eugene Manley, David J Waxman

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Eugene ManleyDivision of Cell and Molecular Biology, Department of Biology, Boston University, 5 Cummington Mall, Boston, MA 02215, USA.
David J WaxmanDivision of Cell and Molecular Biology, Department of Biology, Boston University, 5 Cummington Mall, Boston, MA 02215, USA. Electronic address: djw@bu.edu.
Boston University · US

Funding

HEPATIC METABOLISM OF ANTICANCER DRUGSR01CA049248 · NCI · DANA-FARBER CANCER INSTITUTE · PI WAXMAN, DAVID J · 1991 to 2014
$4.3M
NCI NIH HHS CA49248NCI NIH HHS R01 CA049248
6 · The paper itself

Abstract

Cancer stem-like cells were isolated from several human tumor cell lines by limiting dilution assays and holoclone morphology, followed by assessment of self-renewal capacity, tumor growth, vascularity, and blood perfusion. H460 holoclone-derived tumors grew slower than parental H460 tumors, but displayed significantly increased microvessel density and tumor blood perfusion. Microarray analysis identified 177 differentially regulated genes in the holoclone-derived tumors, of which 47 were associated with angiogenesis. The dysregulated genes include several small leucine-rich proteoglycans that may modulate angiogenesis and serve as novel therapeutic targets for inhibiting cancer stem cell-driven angiogenesis.

Indexed as

AnimalsCarcinoma, Non-Small-Cell LungCell Culture TechniquesCell Line, TumorClone CellsHumansImmunohistochemistryLung NeoplasmsMiceNeoplastic Stem CellsNeovascularization, PathologicOligonucleotide Array Sequence AnalysisPolymerase Chain ReactionXenograft Model Antitumor AssaysAngiogenesisCancer stem-like cellH460 holocloneMicroarraySmall leucine-rich proteoglycan

Identifiers

PMID24334139
PMCPMC3947657
OpenAlexW2155280938

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.