Evidence map›Paper›PMID 24333958›Full record

ArticleJournal of ethnopharmacology2014

New finding of an anti-TB compound in the genus Marsypopetalum (Annonaceae) from a traditional herbal remedy of Laos.

Bethany G Elkington, Kongmany Sydara, Andrew Newsome, Chang Hwa Hwang, David C Lankin, Charlotte Simmler, José G Napolitano, Richard Ree, James G Graham, Charlotte Gyllenhaal and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ethnopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Medicinal Plants in the Treatment of Tuberculosis: A Systematic Review.Central nervous system agents in medicinal chemistry · 2025
    Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Bioactive small-molecule constituents of Lao plants.Journal of medicinal plant research · 2021
    Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Southeast Asian Medicinal Plants as a Potential Source of Antituberculosis Agent.Evidence-based complementary and alternative medicine : eCAM · 2017
    Review
  11. Chemical constituents of the stem ofNatural product research
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Bethany G ElkingtonDepartment of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA; Field Museum of Natural History, 1400 South Lake Shore Drive, Chicago, USA. Electronic address: belkin3@uic.edu.
Kongmany SydaraInstitute of Traditional Medicine, Vientiane, Lao PDR, Laos. Electronic address: kmnkong@gmail.com.
Andrew NewsomeDepartment of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA. Electronic address: anewso2@uic.edu.
Chang Hwa HwangInstitute for Tuberculosis Research, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA. Electronic address: chwang5@uic.edu.
David C LankinDepartment of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA. Electronic address: lankindc@uic.edu.
Charlotte SimmlerDepartment of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA. Electronic address: simmler@uic.edu.
José G NapolitanoDepartment of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA. Electronic address: jgnapo@uic.edu.
Richard ReeField Museum of Natural History, 1400 South Lake Shore Drive, Chicago, USA. Electronic address: rree@fieldmuseum.org.
James G GrahamDepartment of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA; Field Museum of Natural History, 1400 South Lake Shore Drive, Chicago, USA. Electronic address: ucayali@uic.edu.
Charlotte GyllenhaalDepartment of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA. Electronic address: gyllenha@uic.edu.
Somsanith BouamanivongNational Herbarium of Laos, Vientiane, Lao PDR, Laos. Electronic address: bsomsanith@gmail.com.
Onevilay SouliyaInstitute of Traditional Medicine, Vientiane, Lao PDR, Laos. Electronic address: onevilay@gmail.com.
Guido F PauliDepartment of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA. Electronic address: gfp@uic.edu.
Scott G FranzblauDepartment of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA; Institute for Tuberculosis Research, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA. Electronic address: sgf@uic.edu.
Djaja Djendoel SoejartoDepartment of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA; Field Museum of Natural History, 1400 South Lake Shore Drive, Chicago, USA. Electronic address: dds@uic.edu.
University of Illinois Chicago · USField Museum of Natural History · USRural Development Agency · LA

Funding

INVENTORY AND CONSERVATION OF PLANTS OF CUC PHUONG NATIONAL PARKU01TW001015 · FIC · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SOEJARTO, DJAJA D · 1998 to 2010
$7.8M
900MHz NMR for Structural Biology in ChicagoP41GM068944 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GETTINS, PETER G.W. · 2003 to 2007
$6.2M
Anti-Tubercular Plants from Traditional Medicines of LaosF31AT006069 · NCCIH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ELKINGTON, BETHANY GWEN · 2010 to 2012
$125k
FIC NIH HHS 2-U01-TW001015FIC NIH HHS U01 TW001015NCCIH NIH HHS F31 AT006069NCCIH NIH HHS F31AT006069NIGMS NIH HHS P41 GM068944NIGMS NIH HHS P41GM068944
6 · The paper itself

Abstract

ethnopharmacological relevanceThere is widespread use of traditional herbal remedies in the Lao PDR (Laos). It is common practice to treat many diseases with local plants. This research project documented and analysed some of these traditional remedies used to treat symptoms of tuberculosis (TB). MATERIALS AND

methodsThis research was executed by interviewing healers about plants used traditionally to treat the symptoms of TB. Samples of some of the plants were collected, and extracts of 77 species were submitted to various in vitro assays in order to determine the amount of growth inhibition of virulent Mycobacterium tuberculosis H37Rv (Mtb), as opposed to other microbes and mammalian Vero cells.

resultsInterviews took place with 58 contemporary healers in 5 different provinces about plants currently used, giving a list of 341 plants. Bioassay-guided fractionation was performed on Marsypopetalum modestum (Pierre) B. Xue and R.M.K. Saunders (Annonaceae), leading to the isolation of dipyrithione, an anti-mycobacterial compound isolated for the first time from the genus Marsypopetalum through this research.

conclusionsThis research has helped to increase awareness of Laos' rich diversity of medicinal plants and will hopefully provide incentive to preserve the undeveloped forested areas that remain, which still hold a wealth of medical information for future discoveries.

Indexed as

AnnonaceaeAnimalsAntitubercular AgentsChlorocebus aethiopsData CollectionFemaleHumansLaosMaleMedicine, African TraditionalMycobacterium tuberculosisPhytotherapyPlant ExtractsTuberculosisVero CellsAntitubercular AgentsPlant ExtractsAntimycobacteriaCytotoxicityDipyrithione (PubChem CID: 3109)MarsypopetalumMedical ethnobotanyTraditional medicine Asia and Oceania

Identifiers

PMID24333958
PMCPMC3933013
OpenAlexW2089058825

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.