Evidence map›Paper›PMID 24333932›Full record

ArticleBiosensors & bioelectronics2014

Stretchable electrochemical impedance sensors for intravascular detection of lipid-rich lesions in New Zealand White rabbits.

Hung Cao, Fei Yu, Yu Zhao, Nick Scianmarello, Juhyun Lee, Wangde Dai, Nelson Jen, Tyler Beebe, Rongsong Li, Ramin Ebrahimi and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors & bioelectronics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. 3-Dimensional electrical impedance spectroscopy forSensors and actuators. B, Chemical · 2022
    Article
  4. Review
  5. Biosensors for Detection of Human Placental Pathologies: A Review of Emerging Technologies and Current Trends.Translational research : the journal of laboratory and clinical medicine · 2019
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Power Approaches for Implantable Medical Devices.Sensors (Basel, Switzerland) · 2015
    Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hung CaoDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States; Division of Cardiology, Department of Medicine, VA Greater Los Angeles Healthcare System, School of Medicine, University of California, United States.
Fei YuDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States.
Yu ZhaoDepartment of Electrical Engineering, California Institute of Technology, Pasadena, CA, United States.
Nick ScianmarelloDepartment of Electrical Engineering, California Institute of Technology, Pasadena, CA, United States.
Juhyun LeeDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States; Division of Cardiology, Department of Medicine, VA Greater Los Angeles Healthcare System, School of Medicine, University of California, United States.
Wangde DaiThe Heart Institute of Good Samaritan Hospital, Los Angeles, CA, United States.
Nelson JenDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States; Division of Cardiology, Department of Medicine, VA Greater Los Angeles Healthcare System, School of Medicine, University of California, United States.
Tyler BeebeDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States; Division of Cardiology, Department of Medicine, VA Greater Los Angeles Healthcare System, School of Medicine, University of California, United States.
Rongsong LiDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States; Division of Cardiology, Department of Medicine, VA Greater Los Angeles Healthcare System, School of Medicine, University of California, United States.
Ramin EbrahimiDivision of Cardiology, Department of Medicine, VA Greater Los Angeles Healthcare System, School of Medicine, University of California, United States.
Donald S ChangDivision of Cardiology, Department of Medicine, VA Greater Los Angeles Healthcare System, School of Medicine, University of California, United States.
Freny V ModyDivision of Cardiology, Department of Medicine, VA Greater Los Angeles Healthcare System, School of Medicine, University of California, United States.
John PacellaDivision of Cardiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States.
Yu-Chong TaiDepartment of Electrical Engineering, California Institute of Technology, Pasadena, CA, United States.
Tzung HsiaiDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States; Division of Cardiology, Department of Medicine, VA Greater Los Angeles Healthcare System, School of Medicine, University of California, United States. Electronic address: THsiai@mednet.ucla.edu.

Funding

Linking Spatial Variations Shear Stress-Oxidative StressR01HL083015 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HSIAI, TZUNG K · 2006 to 2015
$3.9M
Electronica Impedance to Access Metabolically Active PlaqueR01HL118650 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HSIAI, TZUNG K · 2014 to 2022
$3.3M
Micro-Sensors to Study Electrical and Mechanical Coupling of Injured MyocardiumR01HL111437 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HSIAI, TZUNG K, XU, XIAOLEI · 2012 to 2020
$3.1M
Shear Stress and Mechnaically Unstable PlaqueR21HL091302 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HSIAI, TZUNG K · 2009 to 2010
$432k
NHLBI NIH HHS HL083015NHLBI NIH HHS HL111437NHLBI NIH HHS R01 HL083015NHLBI NIH HHS R01 HL111437NHLBI NIH HHS R01 HL118650NHLBI NIH HHS R21 HL091302
6 · The paper itself

Abstract

Flexible electronics have enabled catheter-based intravascular sensing. However, real-time interrogation of unstable plaque remains an unmet clinical challenge. Here, we demonstrate the feasibility of stretchable electrochemical impedance spectroscopy (EIS) sensors for endoluminal investigations in New Zealand White (NZW) rabbits on diet-induced hyperlipidemia. A parylene C (PAC)-based EIS sensor mounted on the surface of an inflatable silicone balloon affixed to the tip of an interrogating catheter was deployed (1) on the explants of NZW rabbit aorta for detection of lipid-rich atherosclerotic lesions, and (2) on live animals for demonstration of balloon inflation and EIS measurements. An input peak-to-peak AC voltage of 10 mV and sweeping-frequency from 300 kHz to 100 Hz were delivered to the endoluminal sites. Balloon inflation allowed EIS sensors to be in contact with endoluminal surface. In the oxidized low-density-lipoprotein (oxLDL)-rich lesions from explants of fat-fed rabbits, impedance magnitude increased significantly by 1.5-fold across the entire frequency band, and phase shifted ~5° at frequencies below 10 kHz. In the lesion-free sites of the normal diet-fed rabbits, impedance magnitude increased by 1.2-fold and phase shifted ~5° at frequencies above 30 kHz. Thus, we demonstrate the feasibility of stretchable intravascular EIS sensors for identification of lipid rich lesions, with a translational implication for detecting unstable lesions.

Indexed as

AnimalsAortaAtherosclerosisBiosensing TechniquesDielectric SpectroscopyElectric ImpedanceEquipment DesignLipidsLipoproteins, LDLMalePlaque, AtheroscleroticRabbitsLipidsLipoproteins, LDLoxidized low density lipoproteinAtherosclerotic lesionsBalloon inflationElectrochemical impedance spectroscopyNew Zealand White rabbitsStretchable micro-sensor

Identifiers

PMID24333932
PMCPMC4048807

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.