ReviewAdvanced drug delivery reviews2014
C. elegans in high-throughput drug discovery.
Review in Advanced drug delivery reviews, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
124 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Nonmammalian models to study Clostridioides difficile infection; a systematic review.Anaerobe · 2023Pooled it
- Stress induced hyperphagia iniScience · 2026Article
- An automated high-resolution screening platform identifies regulators of anchor cell invasion inScience advances · 2026Article
- A novel anaerobic cholinergic signaling compound, β-alanine betaine, and nAChRs in Ascaris.PLoS neglected tropical diseases · 2026Article
- Review
- Toxicity of Four Common Environmental Chemicals Across Caenorhabditis elegans Life Stages Supporting the One Health Concept.Environmental toxicology · 2026Article
- β-alanine betaine and nAChRs inbioRxiv : the preprint server for biology · 2026Article
- WormSpot: a machine learning-powered viability scoring platform inMicrobiology spectrum · 2026Article
- Article
- G protein regulatory network shapes magnitude and kinetics of behavioral responses in an engineered opioid receptor model.The Journal of biological chemistry · 2026Article
- Chalcone andMolecules (Basel, Switzerland) · 2026Article
- Beyond the mouse: 3R-guided alternative animal models transforming cancer research.Molecular cancer · 2026Review
- Dietary mycotoxin toxicity inAdvances in neurotoxicology · 2026Article
- Alternative methods for developmental toxicity testing: features, status and future directions.Journal of veterinary science · 2025Review
- TheInternational journal of molecular sciences · 2025Article
- Drug screens using the nematode Caenorhabditis elegans.Genetics · 2025Review
- Brief guide to Caenorhabditis elegans survival assays.Molecules and cells · 2025Review
- Review
- First evidence of an anxiety-like behavior and its pharmacological modulation in a molluscan model organism, Lymnaea stagnalis.Translational psychiatry · 2025Article
- Small-molecule screen in C. elegans identifies benzenesulfonamides as inhibitors of microsporidia spores.npj antimicrobials and resistance · 2025Article
64 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Caenorhabditis elegans has been proven to be a useful model organism for investigating molecular and cellular aspects of numerous human diseases. More recently, investigators have explored the use of this organism as a tool for drug discovery. Although earlier drug screens were labor-intensive and low in throughput, recent advances in high-throughput liquid workflows, imaging platforms and data analysis software have made C. elegans a viable option for automated high-throughput drug screens. This review will outline the evolution of C. elegans-based drug screening, discuss the inherent challenges of using C. elegans, and highlight recent technological advances that have paved the way for future drug screens.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.