ReviewMitochondrion2014
Mitochondrial and postmitochondrial survival signaling in cancer.
Review in Mitochondrion, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Recent advances and applications of mitochondria in tumors and inflammation.Journal of translational medicine · 2025Review
- Molecular Perspective of Nanoparticle Mediated Therapeutic Targeting in Breast Cancer: An Odyssey of Endoplasmic Reticulum Unfolded Protein Response (UPRBiomedicines · 2021Review
- Mitochondrial Stress Response and Cancer.Trends in cancer · 2020Review
- Lung cancer increases HHeliyon · 2020Article
- Hsp60 and IL-8 axis promotes apoptosis resistance in cancer.British journal of cancer · 2019Article
- CytochromeCancer research · 2019Article
- Diosgenin Suppresses Cholangiocarcinoma Cells Via Inducing Cell Cycle Arrest And Mitochondria-Mediated Apoptosis.OncoTargets and therapy · 2019Article
- Administration of Ketamine Causes Autophagy and Apoptosis in the Rat Fetal Hippocampus and in PC12 Cells.Frontiers in cellular neuroscience · 2018Article
- Role for the ATPase inhibitory factor 1 in the environmental carcinogen-induced Warburg phenotype.Scientific reports · 2017Article
- Endoplasmic reticulum-mediated unfolded protein response and mitochondrial apoptosis in cancer.Biochimica et biophysica acta. Reviews on cancer · 2017Review
- The Greater Genomic Landscape: The Heterogeneous Evolution of Cancer.Cancer research · 2016Article
- Mitochondrial ClpP activity is required for cisplatin resistance in human cells.Biochimica et biophysica acta · 2016Article
- Resistance to Cell Death and Its Modulation in Cancer Stem Cells.Critical reviews in oncogenesis · 2016Review
- Mechanism of neem limonoids-induced cell death in cancer: Role of oxidative phosphorylation.Free radical biology & medicine · 2016Article
- A potential role of X-linked inhibitor of apoptosis protein in mitochondrial membrane permeabilization and its implication in cancer therapy.Drug discovery today · 2016Review
- Oxidative phosphorylation-dependent regulation of cancer cell apoptosis in response to anticancer agents.Cell death & disease · 2015Article
- Article
- Bisdemethoxycurcumin attenuates gastric adenocarcinoma growth by inducing mitochondrial dysfunction.Oncology letters · 2015Article
- Neem components as potential agents for cancer prevention and treatment.Biochimica et biophysica acta · 2014Review
- Autonomous inhibition of apoptosis correlates with responsiveness of colon carcinoma cell lines to ciglitazone.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Cancer cells are resistant to conventional chemotherapy and radiotherapy, however, the molecular mechanisms of resistance to therapy remain unclear. Cellular survival machinery protects mitochondrial integrity against endogenous or exogenous stresses. Prodeath molecules orchestrate around mitochondria to initiate and execute cell death in cancer, and also play an underappreciated role in survival of cancer cells. Prosurvival mechanisms can operate at mitochondrial and postmitochondrial levels to attenuate core apoptotic death program. It is intriguing to explore how prosurvival and prodeath molecules crosstalk to regulate mitochondrial functions leading to increased cancer cell survival. This review describes some putative survival mechanisms at mitochondria, which may play a role in designing effective agents for cancer prevention and therapy. These survival pathways may also have significance in understanding other human pathophysiological conditions including diabetes, cardiovascular, autoimmune, and neurodegenerative diseases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.