ReviewProgress in retinal and eye research2014
Circadian organization of the mammalian retina: from gene regulation to physiology and diseases.
Review in Progress in retinal and eye research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
108 citing papers in PubMed, 175 citations in OpenAlex.
- Article
- The role of circadian rhythms in the pathogenesis of myopia.Frontiers in physiology · 2026Review
- Exploring the Effects of Blue Light on Circadian Rhythm in SD Rat.Nature and science of sleep · 2026Article
- The interplay between form deprivation and dopamine signaling in regulating the expression of circadian rhythm-related genes in the retina of mice.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Dialogue Between the Clock Gene Bmal1 and Retinopathy: What Is the Exact Relationship?CNS neuroscience & therapeutics · 2025Review
- Article
- A toolbox for navigating and analyzing the spatiotemporal properties of retinal waves.bioRxiv : the preprint server for biology · 2025Article
- Article
- Circadian Clock Deregulation and Metabolic Reprogramming: A System Biology Approach to Tissue-Specific Redox Signaling and Disease Development.International journal of molecular sciences · 2025Review
- Circadian Rhythms in Murine Ocular Tissues Including Sclera Are Affected by Neurobasal A Medium Preincubation and Mouse Strain, but Not Sex.Investigative ophthalmology & visual science · 2025Article
- Physical activity stimulates clock neurons of the day-active rodentProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Circadian clock disruption promotes retinal photoreceptor degeneration.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Melatonin effects on animal behavior: circadian rhythm, stress response, and modulation of behavioral patterns.Journal of animal science and technology · 2025Review
- Circadian clocks and their role in kidney and eye diseases across organ systems.Frontiers in physiology · 2025Review
- Sleep Duration, Sleep Habits, and Social Jetlag From 4 to 6 years Their Impacts on Myopia Among School-Aged Children: The Ma'anshan Birth Cohort Study.Nature and science of sleep · 2025Article
- Evaluation of insomnia effect on ganglion cell complex, middle retina, and choroid.International ophthalmology · 2024Article
- The Effects of STRA6 Regulation of the Circadian Rhythm on Choroidal Neovascularization.Investigative ophthalmology & visual science · 2024Article
- Altered Outer Retinal Structure, Electrophysiology and Visual Perception in Parkinson's Disease.Journal of Parkinson's disease · 2024Article
- Circadian clock organization in the retina: From clock components to rod and cone pathways and visual function.Progress in retinal and eye research · 2023Review
- Molecular encoding of stimulus features in a single sensory neuron type enables neuronal and behavioral plasticity.Current biology : CB · 2023Article
48 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
The retinal circadian system represents a unique structure. It contains a complete circadian system and thus the retina represents an ideal model to study fundamental questions of how neural circadian systems are organized and what signaling pathways are used to maintain synchrony of the different structures in the system. In addition, several studies have shown that multiple sites within the retina are capable of generating circadian oscillations. The strength of circadian clock gene expression and the emphasis of rhythmic expression are divergent across vertebrate retinas, with photoreceptors as the primary locus of rhythm generation in amphibians, while in mammals clock activity is most robust in the inner nuclear layer. Melatonin and dopamine serve as signaling molecules to entrain circadian rhythms in the retina and also in other ocular structures. Recent studies have also suggested GABA as an important component of the system that regulates retinal circadian rhythms. These transmitter-driven influences on clock molecules apparently reinforce the autonomous transcription-translation cycling of clock genes. The molecular organization of the retinal clock is similar to what has been reported for the SCN although inter-neural communication among retinal neurons that form the circadian network is apparently weaker than those present in the SCN, and it is more sensitive to genetic disruption than the central brain clock. The melatonin-dopamine system is the signaling pathway that allows the retinal circadian clock to reconfigure retinal circuits to enhance light-adapted cone-mediated visual function during the day and dark-adapted rod-mediated visual signaling at night. Additionally, the retinal circadian clock also controls circadian rhythms in disk shedding and phagocytosis, and possibly intraocular pressure. Emerging experimental data also indicate that circadian clock is also implicated in the pathogenesis of eye disease and compelling experimental data indicate that dysfunction of the retinal circadian system negatively impacts the retina and possibly the cornea and the lens.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.