ArticleGene expression patterns : GEP2014
Expression of LIM-homeodomain transcription factors in the developing and mature mouse retina.
Article in Gene expression patterns : GEP, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 50 citations in OpenAlex.
- The extreme diversity of retinal amacrine cells has deep evolutionary roots.Science advances · 2026Article
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- The Extreme Diversity Of Retinal Amacrine Cells Has Deep Evolutionary Roots.bioRxiv : the preprint server for biology · 2026Article
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- Lhx4 surpasses its paralog Lhx3 in promoting the differentiation of spinal V2a interneurons.Cellular and molecular life sciences : CMLS · 2024Article
- Single-cell analyses reveal transient retinal progenitor cells in the ciliary margin of developing human retina.Nature communications · 2024Article
- Multiomic Analysis of Neurons with Divergent Projection Patterns Identifies Novel Regulators of Axon Pathfinding.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- RB1 loss triggers dependence on ESRRG in retinoblastoma.Science advances · 2022Article
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- BAF (mSWI/SNF) complex regulates mediolateral cortical patterning in the developing forebrain.Frontiers in cell and developmental biology · 2022Article
- Genome-wide analysis of retinal transcriptome reveals common genetic network underlying perception of contrast and optical defocus detection.BMC medical genomics · 2021Article
- Genetic control of retinal ganglion cell genesis.Cellular and molecular life sciences : CMLS · 2021Review
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- LIM Homeobox 4 (lhx4) regulates retinal neural differentiation and visual function in zebrafish.Scientific reports · 2021Article
- LIM-Homeodomain Transcription Factor LHX4 Is Required for the Differentiation of Retinal Rod Bipolar Cells and OFF-Cone Bipolar Subtypes.Cell reports · 2020Article
- Generation and characterization of Lhx4Genesis (New York, N.Y. : 2000) · 2019Article
- Global Analysis of Intercellular Homeodomain Protein Transfer.Cell reports · 2019Article
- Identification of Genes With Enriched Expression in Early Developing Mouse Cone Photoreceptors.Investigative ophthalmology & visual science · 2019Article
- Heterozygous LHX3 mutations may lead to a mild phenotype of combined pituitary hormone deficiency.European journal of human genetics : EJHG · 2019Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
LIM-homeodomain (LIM-HD) transcription factors have been extensively studied for their role in the development of the central nervous system. Their function is key to several developmental events like cell proliferation, differentiation and subtype specification. However, their roles in retinal neurogenesis remain largely unknown. Here we report a detailed expression study of LIM-HD transcription factors LHX9 and LHX2, LHX3 and LHX4, and LHX6 in the developing and mature mouse retina using immunohistochemistry and in situ hybridization techniques. We show that LHX9 is expressed during the early stages of development in the retinal ganglion cell layer and the inner nuclear layer. We also show that LHX9 is expressed in a subset of amacrine cells in the adult retina. LHX2 is known to be expressed in retinal progenitor cells during development and in Müller glial cells and a subset of amacrine cells in the adult retina. We found that the LHX2 subset of amacrine cells is not cholinergic and that a very few of LHX2 amacrine cells express calretinin. LHX3 and LHX4 are expressed in a subset of bipolar cells in the adult retina. LHX6 is expressed in cells in the ganglion cell layer and the neuroblast layer starting at embryonic stage 13.5 (E13.5) and continues to be expressed in cells in the ganglion cell layer and inner nuclear layer, postnatally, suggesting its likely expression in amacrine cells or a subset thereof. Taken together, our comprehensive assay of expression patterns of LIM-HD transcription factors during mouse retinal development will help further studies elucidating their biological functions in the differentiation of retinal cell subtypes.
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