ArticleNanomedicine : nanotechnology, biology, and medicine2014
Magnetic nanoparticle-based immunoassay for rapid detection of influenza infections by using an integrated microfluidic system.
Article in Nanomedicine : nanotechnology, biology, and medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- A Systematic Review of New, Enhanced Surveillance Systems and Methodologies for Zoonotic Influenza Viruses in Animals and Human-Animal Interface.Influenza and other respiratory viruses · 2025Pooled it
- Evaluation of Viral Collection Efficiency with Antibody-Modified Magnetic Particles by Polymerase Chain Reaction Assay.Sensors (Basel, Switzerland) · 2026Article
- Emerging Trends of Gold Nanostructures for Point-of-Care Biosensor-Based Detection of COVID-19.Molecular biotechnology · 2025Review
- Magnetic nanoparticles fabricated/integrated with microfluidics for biological applications: A review.Biomedical microdevices · 2024Review
- A Microfluidic Platform Revealing Interactions between Leukocytes and Cancer Cells on Topographic Micropatterns.Biosensors · 2022Article
- Nanomaterial-assisted microfluidics for multiplex assays.Mikrochimica acta · 2022Review
- Specific and sensitive detection of Influenza A virus using a biotin-coated nanoparticle enhanced immunomagnetic assay.Analytical and bioanalytical chemistry · 2022Article
- A Methodical Review on the Applications and Potentialities of Using Nanobiosensors for Disease Diagnosis.BioMed research international · 2022Review
- Magnetic Nanoparticles in Biology and Medicine: Past, Present, and Future Trends.Pharmaceutics · 2021Review
- Biomedical Science to Tackle the COVID-19 Pandemic: Current Status and Future Perspectives.Molecules (Basel, Switzerland) · 2020Review
- Point-of-Use Rapid Detection of SARS-CoV-2: Nanotechnology-Enabled Solutions for the COVID-19 Pandemic.International journal of molecular sciences · 2020Review
- Simultaneous and automated detection of influenza A virus hemagglutinin H7 and H9 based on magnetism and size mediated microfluidic chip.Sensors and actuators. B, Chemical · 2020Article
- Recent Advances in AIV Biosensors Composed of Nanobio Hybrid Material.Micromachines · 2018Review
- Facile aerobic construction of iron based ferromagnetic nanostructures by a novel microbial nanofactory isolated from tropical freshwater wetlands.Microbial cell factories · 2017Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Magnetic manganese ferrite (MnFe2O4) nanoparticles with approximately 100nm in diameter were used to improve the performance of an immunoassay for detecting influenza infections. The synthesized nanoparticles were tested for long-term storage to confirm the stability of their thermal decomposition process. Then, an integrated microfluidic system was developed to perform the diagnosis process automatically, including virus purification and detection. To apply these nanoparticles for influenza diagnosis, a micromixer was optimized to reduce the dead volume within the microfluidic chip. Furthermore, the mixing index of the micromixer could achieve as high as 97% in 2seconds. The optical signals showed that this nanoparticle-based immunoassay with dynamic mixing could successfully achieve a detection limit of influenza as low as 0.007 HAU. When compared with the 4.5-μm magnetic beads, the optical signals of the MnFe2O4 nanoparticles were twice as sensitive. Furthermore, five clinical specimens were tested to verify the usability of the developed system. FROM THE CLINICAL EDITOR: In this study, magnetic manganese ferrite nanoparticles were used to improve the performance of a novel immunoassay for the rapid and efficient detection of influenza infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.